Jun 12, 2016

Learning from critical care management of sheep receiving extra-corporeal membrane oxygenation for smoke-induced acute lung injury as a tool for processing large clinical datasets

BioRxiv : the Preprint Server for Biology
Saul Chemonges

Abstract

Background: Many successful therapies developed for human medicine involve animal experimentation. With competition for public research funding and career advancement opportunities, animal studies focused on the translational potential may not sufficiently document unexpected outcomes. Such studies often have hastily developed methods with ad hoc modifications including the use of additional animals, leading to considerable amounts of idle, unprocessed data that could be used to advance veterinary science, or to refine the base animal model. Sheep, for example, are poorly understood models of intensive care and therefore, any experimental data arising from them should be interpreted with care. The hypothesis was that there is little information describing the development of methods of physiological data processing in multifaceted sheep models of intensive care and the author aimed to develop a suitable data processing method and to analyse the data, once processed. Methods: Data from 19 adult mechanically ventilated ewes undergoing intensive care in a previous study evaluating a form of extracorporeal life support (treatment) for acute lung injury were used to develop a comprehensive method for processing manual and electronica...Continue Reading

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Mentioned in this Paper

Study
Body Part
Alveolar Ventilation Function
Lung
Public Health Applications Research
Extracorporeal
Cell Respiration
Oxygen Measurement, Partial Pressure, Arterial
Patient Care
Evaluation

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