PMID: 9163291Jun 1, 1997Paper

Learning from our patients: one participant's impact on clinical trial research and informed consent

Annals of Internal Medicine
C K DaughertyG Zimmer

Abstract

This Perspective includes an essay on modifying phase I clinical trials, written by George Zimmer, who was a professor of English and a commentary on that essay. Professor Zimmer was a cancer patient who participated in the phase I clinical trial program at the University of Chicago. His ideas are eloquently expressed and have had a profound effect on our investigational research for anticancer agents. Although at times his suggestions may seem radical, Professor Zimmer urges us to reconsider the 50-year-old Nuremberg paradigm that participants in human research are ignorant and vulnerable and must be protected. Although we must protect patients who have life-threatening diseases from coercive inducements and misplaced hopes, we must also listen carefully and thoughtfully to our patients. This is particularly true when, as research participants in the face of sacrifice and the threat of a life-ending diagnosis, they have made the effort to express their concerns. With the effect of the acquired immunodeficiency syndrome movement on clinical studies and on drug research and development, a precedent has been set that allows patients to reshape their role as participants in research trials. On a personal level, the essay by Profes...Continue Reading

Citations

Feb 13, 2001·British Journal of Haematology·S BenjaminC A Stiller
Mar 5, 2005·The New England Journal of Medicine·Elizabeth HorstmannChristine Grady
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