Abstract
This Perspective includes an essay on modifying phase I clinical trials, written by George Zimmer, who was a professor of English and a commentary on that essay. Professor Zimmer was a cancer patient who participated in the phase I clinical trial program at the University of Chicago. His ideas are eloquently expressed and have had a profound effect on our investigational research for anticancer agents. Although at times his suggestions may seem radical, Professor Zimmer urges us to reconsider the 50-year-old Nuremberg paradigm that participants in human research are ignorant and vulnerable and must be protected. Although we must protect patients who have life-threatening diseases from coercive inducements and misplaced hopes, we must also listen carefully and thoughtfully to our patients. This is particularly true when, as research participants in the face of sacrifice and the threat of a life-ending diagnosis, they have made the effort to express their concerns. With the effect of the acquired immunodeficiency syndrome movement on clinical studies and on drug research and development, a precedent has been set that allows patients to reshape their role as participants in research trials. On a personal level, the essay by Profes...Continue Reading
Citations
Feb 13, 2001·British Journal of Haematology·S BenjaminC A Stiller
Mar 5, 2005·The New England Journal of Medicine·Elizabeth HorstmannChristine Grady
Sep 17, 2002·The Journal of Legal Medicine·Ben A Rich
Aug 19, 1999·Cancer Nursing·M Krishnasamy
Mar 16, 2011·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Victoria A MillerRobert M Nelson
Aug 2, 2007·Cancer Nursing·Hannah M LindenJoann G Elmore
May 13, 2014·Journal of Pain & Palliative Care Pharmacotherapy·Alex Dubov
May 15, 2015·The American Journal of Bioethics : AJOB·John J Paris, Andrew Hawkins
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manish AgrawalEzekiel J Emanuel
Sep 24, 2002·Cadernos de saúde pública·Douglas P Lackey
Oct 31, 2008·Accountability in Research·Robin Pierce
Sep 24, 2004·Psycho-oncology·Christopher K DaughertyJessica Tartaro
Oct 7, 2004·Bioethics·Atsushi AsaiTsuguya Fukui
Jul 14, 2007·Cancer·Shlomo A KoyfmanCary P Gross
Oct 8, 2015·Academic Medicine : Journal of the Association of American Medical Colleges·Rebecca N JeromeJill M Pulley
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C K Daugherty