Learning impairment in 1-2-day-old epileptic chicks

Epilepsia
D D Gervais-Fagnou, J M Tuchek

Abstract

The cause of learning impairment in children with seizure disorders is obscure, in part because of the lack of adequate animal models of learning deficiencies that can be used for study. The discriminating passive avoidance test has been used extensively to study learning behavior in chicks. In the present study, we applied the passive avoidance test to epileptic chicks to determine if learning deficiencies could be demonstrated in this epileptic model. Epileptic fowl have a hereditary form of primary generalized epilepsy characterized by tonic-clonic seizures. The seizures occur spontaneously and can also be induced by photic stimulation. The epileptic phenotype is the result of an autosomal recessive mutation. Heterozygotes do not have seizures and were used as age-matched controls. The discriminating passive avoidance test used in the present study was based on the observation that chicks readily peck at bright shiny beads. Once chicks taste a colored bead coated with a bitter chemical (methylanthranilate), they refuse to peck the bead on subsequent presentations. In addition, chicks can discriminate between colored beads and will continue to peck at a bead of different color than the methylanthranilate (MeA)-coated bead. co...Continue Reading

References

Jul 1, 1979·Journal of Experimental Psychology. Animal Behavior Processes·D J Gillan
Apr 1, 1978·Canadian Journal of Physiology and Pharmacology·H L DavisR D Crawford
Aug 1, 1977·Canadian Journal of Physiology and Pharmacology·D D JohnsonR D Crawford
Jan 1, 1992·Behavioral and Neural Biology·A BeckerH Matthies
May 24, 1988·Brain Research·W S Stone, P E Gold
Jan 16, 1986·Neuroscience Letters·F H Lopes da SilvaW J Wadman
May 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·C A HawkinsJ Brown
Oct 1, 1974·Canadian Journal of Physiology and Pharmacology·D D JohnsonR D Crawford
Jun 1, 1974·Canadian Journal of Physiology and Pharmacology·E C Crichlow, R D Crawford
Feb 27, 1970·Science·D A Pollen, M C Trachtenberg
Sep 1, 1970·The Journal of Heredity·R D Crawford
May 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·A BeckerH Matthies

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Citations

Nov 16, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Daniel MargoliashMichael Kohrman

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