Learning modulation by endogenous hippocampal IL-1: blockade of endogenous IL-1 facilitates memory formation

Hippocampus
Amaicha M DepinoFernando Pitossi

Abstract

The interleukin-1 (IL-1) cytokine family (IL-1alpha, IL-beta, and the IL-1 receptor antagonist) is involved in immune and inflammatory responses both in the brain and in the periphery. Recently, it has also been shown to influence behavior and memory consolidation. However, within the experimental systems studied, it has remained unclear whether the role of IL-1beta is associated solely with a pathophysiological process or whether it is a neuromodulator in normal adult brain. To evaluate the involvement of the nonpathological endogenous IL-1 system in learning, we studied the expression of IL-1alpha, IL-1beta, and IL-1ra during memory consolidation. We observed a learning-specific hippocampal IL-1alpha mRNA induction, but not that of IL-1beta or IL-1ra mRNAs, after inhibitory avoidance training. Moreover, when IL-1 receptor activity was inhibited using an adenoviral vector that expresses the IL-1 receptor antagonist (IL-1ra) in the hippocampus, both short-term and long-term memory retention scores were facilitated. In contrast, endogenous hippocampal IL-1 played no role in the habituation to a novel environment. These results demonstrate that endogenous hippocampal IL-1 specifically modulates a fear-motivated learning task, and...Continue Reading

References

Nov 1, 1991·Immunology Today·C A Dinarello, R C Thompson
Jul 1, 1986·Behavioral and Neural Biology·P E Gold
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jun 14, 1967·Journal of Molecular Biology·B Hirt
Feb 1, 1995·Trends in Neurosciences·S J Hopkins, N J Rothwell
Jan 1, 1994·European Journal of Pharmacology·C R Plata-Salamán, J M ffrench-Mullen
Jan 1, 1994·Advances in Pharmacology·N J Rothwell, G Luheshi
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·R BernabeuJ H Medina
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·H SchneiderH O Besedovsky
Jun 26, 1998·Nature·I IzquierdoJ H Medina
Jul 4, 1998·Brain Research. Brain Research Reviews·S A LoddickE B De Souza
Jul 29, 1998·Neuroscience·C M ThielR K Schwarting
Sep 30, 1998·Journal of Neuroscience Research·M BianchiA E Panerai
Dec 1, 1998·The Journal of Physiology·N J Rothwell
Apr 10, 1999·Nature Neuroscience·C M AtkinsJ D Sweatt
Apr 16, 1999·Nature Neuroscience·S M TaubenfeldC M Alberini
Oct 8, 1999·Behavioural Brain Research·H Eichenbaum
Jan 15, 2000·Science·J L McGaugh
Jan 26, 2000·Journal of Neurochemistry·L VitkovicC Jacque
Nov 18, 2000·Analytical Biochemistry·M J AlvarezF J Pitossi
Feb 13, 2001·Neuroscience and Biobehavioral Reviews·C Rachal PughJ W Rudy
Dec 26, 2001·Neurobiology of Learning and Memory·Mariana AlonsoJorge H Medina
May 10, 2002·Annals of the New York Academy of Sciences·R Dantzer
May 17, 2002·Current Opinion in Neurobiology·James L McGaugh, Benno Roozendaal

❮ Previous
Next ❯

Citations

May 26, 2005·Brain, Behavior, and Immunity·Martin D CarmichaelAbdul Ghaffar
Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ofra Ben Menachem-ZidonRaz Yirmiya
May 28, 2008·Brain : a Journal of Neurology·María Clara Pott GodoyFernando Juan Pitossi
Oct 6, 2005·Learning & Memory·Mariana AlonsoJorge H Medina
Dec 13, 2007·Neuroimmunomodulation·Gustavo Pacheco-LópezManfred Schedlowski
Feb 28, 2008·Journal of Neuroinflammation·Solomon S ShaftelM Kerry O'Banion
Nov 10, 2013·PloS One·Carol L MurrayColm Cunningham
Jan 28, 2014·Neuroscience and Biobehavioral Reviews·Holly F Green, Yvonne M Nolan
Feb 18, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emrin HorgusluogluAndrew J Saykin
Dec 24, 2015·Neuroscience and Biobehavioral Reviews·Sinéad M Ryan, Yvonne M Nolan
Jan 6, 2016·Translational Psychiatry·S MonteiroJ J Cerqueira
Mar 8, 2011·Trends in Molecular Medicine·Seth L Masters, Luke A J O'Neill
Nov 26, 2010·Brain, Behavior, and Immunity·Ofra Ben Menachem-ZidonRaz Yirmiya
Jan 1, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·David StaceyBernhard T Baune
Nov 20, 2008·Frontiers in Neuroendocrinology·Inbal Goshen, Raz Yirmiya
Sep 18, 2008·Behavioural Brain Research·Laure BarbierWilliam Fauquette
Nov 3, 2007·Psychoneuroendocrinology·Inbal GoshenRaz Yirmiya
Apr 6, 2007·Brain Research Reviews·Larisa B Goncharova, Alexander O Tarakanov
Dec 13, 2006·Brain, Behavior, and Immunity·Hugo O Besedovsky, Adriana Del Rey
Jul 25, 2012·Annals of the New York Academy of Sciences·Adriana del ReyHugo O Besedovsky
Sep 16, 2006·Neuroscience Letters·A Vania ApkarianAdriana del Rey
Aug 26, 2014·Neurobiology of Learning and Memory·Elissa J Donzis, Natalie C Tronson
Jan 25, 2012·Molecular and Cellular Neurosciences·Holly F GreenYvonne M Nolan
Jan 30, 2013·Neurobiology of Learning and Memory·Gisele Agustini LovatelIonara Rodrigues Siqueira
Nov 29, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Meghan E JonesDonald T Lysle
May 25, 2016·Neuroscience and Biobehavioral Reviews·Shruti VishnoiSuhel Parvez
Jul 26, 2016·Frontiers in Physiology·Nadia KazlauskasFernando F Locatelli
Nov 11, 2008·Neuroscience and Biobehavioral Reviews·J McAfoose, B T Baune
Jan 5, 2020·Expert Opinion on Therapeutic Targets·Alessandra MusellaGeorgia Mandolesi
Jun 5, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lucas Taoro-GonzálezVicente Felipo
Oct 28, 2019·Cells·Marcus Augusto-OliveiraMaria Elena Crespo-Lopez
Nov 11, 2017·Frontiers in Behavioral Neuroscience·Takako TakemiyaMarumi Kawakami
Feb 8, 2018·Frontiers in Neurology·Xiaoyu Liu, Ning Quan
Oct 21, 2020·Molecular Neurobiology·Mohammad Azizur RahmanMd Alamin
Dec 10, 2020·Brain and Behavior·Roberto ZefferinoMassimo Conese

❮ Previous
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