Learning place cells, grid cells and invariances with excitatory and inhibitory plasticity

ELife
Simon Nikolaus Weber, Henning Sprekeler

Abstract

Neurons in the hippocampus and adjacent brain areas show a large diversity in their tuning to location and head direction, and the underlying circuit mechanisms are not yet resolved. In particular, it is unclear why certain cell types are selective to one spatial variable, but invariant to another. For example, place cells are typically invariant to head direction. We propose that all observed spatial tuning patterns - in both their selectivity and their invariance - arise from the same mechanism: Excitatory and inhibitory synaptic plasticity driven by the spatial tuning statistics of synaptic inputs. Using simulations and a mathematical analysis, we show that combined excitatory and inhibitory plasticity can lead to localized, grid-like or invariant activity. Combinations of different input statistics along different spatial dimensions reproduce all major spatial tuning patterns observed in rodents. Our proposed model is robust to changes in parameters, develops patterns on behavioral timescales and makes distinctive experimental predictions.

References

Apr 1, 1976·Experimental Neurology·J O'Keefe
Jan 1, 1996·Annual Review of Neuroscience·K Tanaka
Oct 14, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J O'KeefeE A Maguire
Dec 24, 2002·Neuron·Albert K Lee, Matthew A Wilson
Aug 31, 2004·Science·Marianne FyhnMay-Britt Moser
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark C Fuhs, David S Touretzky
Jul 22, 2006·Nature Reviews. Neuroscience·Bruce L McNaughtonMay-Britt Moser
Nov 10, 2006·Hippocampus·Trygve SolstadGaute T Einevoll
Dec 13, 2006·Network : Computation in Neural Systems·Edmund T RollsThomas Elliot
Dec 30, 2006·Journal of Computational Neuroscience·M FranziusL Wiskott
Feb 27, 2007·Nature·Marianne FyhnEdvard I Moser
Mar 30, 2007·Journal of Neurophysiology·W Bryan Wilent, Douglas A Nitz
Jun 29, 2007·Hippocampus·Neil BurgessJohn O'Keefe
Jul 17, 2007·Trends in Cognitive Sciences·James J DiCarlo, David D Cox
Sep 6, 2007·PLoS Computational Biology·Mathias FranziusLaurenz Wiskott
Feb 21, 2008·Annual Review of Neuroscience·Edvard I MoserMay-Britt Moser
May 16, 2008·Nature·Torkel HaftingEdvard I Moser
Jun 6, 2008·Hippocampus·Colin Molter, Yoko Yamaguchi
Nov 21, 2008·Hippocampus·Vegard Heimly BrunMay-Britt Moser
Nov 21, 2008·Hippocampus·Emilio Kropff, Alessandro Treves
Feb 21, 2009·PLoS Computational Biology·Yoram Burak, Ila R Fiete
Mar 21, 2009·Nature Reviews. Neuroscience·N M van StrienM P Witter
Sep 15, 2009·PLoS Computational Biology·Balázs UjfalussyPéter Erdi
Apr 2, 2010·Journal of Neurophysiology·Francesco Savelli, James J Knierim
Jun 19, 2010·Science·Tom J WillsJohn O'Keefe
Jun 19, 2010·Science·Rosamund F LangstonMay-Britt Moser
Sep 8, 2010·The Journal of Physiology·Balázs HangyaAndrás Czurkó
Aug 9, 2011·Current Opinion in Neurobiology·Neil Burgess, John O'Keefe
Aug 27, 2011·Neuron·Lisa M GiocomoEdvard I Moser
Apr 25, 2012·Frontiers in Neural Circuits·Eric A Zilli
Aug 16, 2012·Biological cybernetics·Bailu SiAlessandro Treves
Aug 21, 2012·Science·Julija KrupicJohn O'Keefe
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Caswell BarryNeil Burgess
Dec 12, 2012·Nature·Hanne StensolaEdvard I Moser

❮ Previous
Next ❯

Citations

Mar 12, 2020·International Journal of Molecular Sciences·Daniela GandolfiJonathan Mapelli
Aug 28, 2020·Computational Intelligence and Neuroscience·Kun HanLei Lai
Oct 7, 2020·Hippocampus·Tiziano D'Albis, Richard Kempter
Oct 6, 2020·Frontiers in Neural Circuits·Ehud VinepinskyRonen Segev
Apr 27, 2021·ELife·Owen MackwoodHenning Sprekeler
Jun 13, 2021·Nature Communications·Michael D AdoffDaniel A Dombeck
Aug 13, 2021·Nature·Gily GinosarNachum Ulanovsky
Aug 29, 2021·Nature Reviews. Neuroscience·Jon W RueckemannElizabeth A Buffalo
Nov 9, 2021·PLoS Computational Biology·Filip VercruysseHenning Sprekeler
Nov 12, 2021·PLoS Computational Biology·Júlia V Gallinaro, Claudia Clopath
Jul 14, 2021·Physiological Reviews·John J TukkerDietmar Schmitz
Jan 14, 2022·Nature·Richard J GardnerEdvard I Moser

❮ Previous
Next ❯

Software Mentioned

CAN

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.