Learning Promotes Subfield-Specific Synaptic Diversity in Hippocampal CA1 Neurons

Cerebral Cortex
Y SakimotoDai Mitsushima

Abstract

The hippocampus is functionally heterogeneous between the dorsal and ventral subfields with left-right asymmetry. To determine the possible location of contextual memory, we performed an inhibitory avoidance task to analyze synaptic plasticity using slice patch-clamp technique. The training bilaterally increased the AMPA/NMDA ratio at dorsal CA3-CA1 synapses, whereas the training did not affect the ratio at ventral CA3-CA1 synapses regardless of the hemisphere. Moreover, sequential recording of miniature excitatory postsynaptic currents and miniature inhibitory postsynaptic currents from the same CA1 neuron clearly showed learning-induced synaptic plasticity. In dorsal CA1 neurons, the training dramatically strengthened both excitatory and inhibitory postsynaptic responses in both hemispheres, whereas the training did not promote the plasticity in either hemisphere in ventral CA1 neurons. Nonstationary fluctuation analysis further revealed that the training bilaterally increased the number of AMPA or GABAA receptor channels at dorsal CA1 synapses, but not at ventral CA1 synapses, suggesting functional heterogeneity of learning-induced receptor mobility. Finally, the performance clearly impaired by the bilateral microinjection o...Continue Reading

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Citations

Nov 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuya SakimotoDai Mitsushima

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Methods Mentioned

BETA
dissection

Software Mentioned

Clampfit
Excel
MATLAB
Clampex
R Foundation for Statistical
R

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