Learning to control tissue damage while fighting Aspergillus

Medical Mycology
Alicia Yoke Wei WongTeresa Zelante

Abstract

Aspergillus moulds are increasingly being recognised as significant human pathogens that can cause life-threatening infections in the context of host immune dysregulation, particularly in the lung. It is now clear that there is a close relationship between infection susceptibility and the fine regulation of pulmonary immunity and inflammation. While the contribution of IL-17/Th17 responses to both physiological and pathological lung inflammation is now well established, the cellular interactions, soluble factors, and signalling pathways that determine Th17 cell responses to fungal infection remain unclear. Here, we identify potential key mediators of fungus-DC-T cell interactions in the respiratory tract, with a focus on the DC-derived cytokines thought to exert a major influence on generation of pathological Th17 cells. We review recent data indicating a crucial role for Aspergillus-induced autophagy in lung DCs on subsequent T-cell polarization and modulation of 'stemness', which appears critical for avoiding pathological lung inflammation and promoting disease resolution.

References

Aug 30, 2001·Nature Immunology·F GranucciP Ricciardi-Castagnoli
May 2, 2002·Cell·Gerald R Crabtree, Eric N Olson
Sep 26, 2002·Trends in Immunology·Thomas R Malek
Oct 9, 2002·Nature Immunology·Ursula GrohmannPaolo Puccetti
May 10, 2003·Trends in Immunology·Ursula GrohmannPaolo Puccetti
Oct 18, 2005·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia MontagnoliLuigina Romani
Mar 7, 2006·Trends in Microbiology·Luigina Romani, Paolo Puccetti
Dec 13, 2006·Transplant Immunology·Vanessa OliveiraLuis Graca
Feb 6, 2007·American Journal of Clinical Pathology·Theodouli StergiopoulouThomas J Walsh
Feb 6, 2007·Nature Genetics·Jun YamanouchiPere Santamaria
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helen S GoodridgeDavid M Underhill
Mar 17, 2007·Immunity·Arian LaurenceJohn J O'shea
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Allison L BayerThomas R Malek
May 4, 2007·The Journal of Clinical Investigation·David H Munn, Andrew L Mellor
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser
Sep 28, 2007·European Journal of Immunology·Teresa ZelanteLuigina Romani
Dec 8, 2007·Annual Review of Immunology·Thomas R Malek
Jul 9, 2008·Medical Mycology·Luigina RomaniPaolo Puccetti
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria L BelladonnaPaolo Puccetti
Nov 15, 2008·Microbes and Infection·Teresa ZelanteLuigina Romani
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca FallarinoUrsula Grohmann
Oct 6, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Agnès GardetDaniel K Podolsky
Mar 12, 2011·Nature Reviews. Immunology·Luigina Romani
Dec 20, 2011·Immunity·Pawel MuranskiNicholas P Restifo
Jan 19, 2012·Infection and Immunity·Benjamin J MurdockGary B Huffnagle
Feb 7, 2012·Cell Stem Cell·C John Luckey, Casey T Weaver
Mar 1, 2012·Science·Ruslan MedzhitovMiguel P Soares
Jun 22, 2012·Frontiers in Immunology·Teresa ZelantePaola Ricciardi-Castagnoli
Jan 12, 2013·American Journal of Respiratory and Critical Care Medicine·Rossana G IannittiLuigina Romani
Mar 5, 2013·Nature Neuroscience·Samantha J OrensteinAna Maria Cuervo
Mar 19, 2013·American Journal of Respiratory and Critical Care Medicine·Keven M Robinson, John F Alcorn

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Citations

Aug 27, 2021·Journal of Fungi·Zhaohong TanLouis Yi Ann Chai

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