Leaves of Spondias mombin L. a traditional anxiolytic and antidepressant: Pharmacological evaluation on zebrafish (Danio rerio)

Journal of Ethnopharmacology
Tafnis Ingret Dos Santos SampaioJosé Carlos Tavares Carvalho

Abstract

Spondias mombin L. is a plant dispersed throughout the tropical regions of South America, Africa, and Asia, being found mainly in the North and Northeast of Brazil, where the leaves are used in preparations for neuropsychiatric disorders. Therefore, it is of great importance to carry out studies in different pharmacological models that can prove the traditional use of this plant species. the hydroethanolic extract from S. mombin leaves (HELSm) was evaluated by oral administration (25 mg/kg) and by immersion (25 mg/l) in scototaxis test in zebrafish (Danio rerio). For this study, caffeine (100 mg/kg) and buspirone (25 mg/kg) were used as standard drugs. The antidepressant action of the HELSm was evaluated assessed in the novel tank diving test (NTDT). In this study, a group with 1% ethanol, one with unpredictable chronic mild stress (UCMS), and another with developmental, social isolation (DSI) were used as induction groups for depression-like behavior and fluoxetine (20 mg/kg) as a drug pattern. by the HPLC-UV fingerprint analysis, the HELSm presented several derivatives of polyphenolic compounds and flavonoids and identified ellagic acid and isoquercitrin, and by the gas-chromatographic, the majority of the identified compound...Continue Reading

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Citations

Dec 15, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Glaucia Dal SantoAlmir Gonçalves Wanderley
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Elaine ArarunaVanda Santos
May 31, 2020·Journal of Ethnopharmacology·Ana Carolina Mendes HackeRomaiana Picada Pereira
Nov 3, 2020·Journal of Ethnopharmacology·A Anand GanapathyAlaganandam Kumaran

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