PMID: 2117208Jan 1, 1990Paper

Lecithin/sphingomyelin ratio from tracheal aspirates and compliance of the respiratory system in infants with bronchopulmonary dysplasia

Lung
E KattnerP Stevens

Abstract

In 55 infants with respiratory distress syndrome the dynamic compliance of the respiratory system (CRS) was measured by pneumotachography during the course of the disease. Lecithin/sphingomyelin ratio (L/S) was evaluated at birth and every 10th day. Thirteen infants who developed bronchopulmonary dysplasia (BPD) had lower L/S ratios at birth than those infants without BPD (mean = 1.0 versus 3.5, p less than 0.01). During the course of disease, L/S ratios were variable and increased in all infants independently of outcome. In the first days of life CRS was low (0.30 ml/cm H2O/kg) in all infants independently of outcome. In infants with BPD who survived, CRS was significantly higher from the 30th day on than in infants who died from the disease (0.35 versus 0.23 ml/cm H2O/kg). Together with an decrease in oxygen supply at this time (less than 70%) the CRS is a reliable predictor of survival in cases of BPD.

References

Jul 3, 1978·European Journal of Pediatrics·M Obladen
Jan 1, 1979·American Journal of Obstetrics and Gynecology·S W MacDonaldJ A Embil
Jan 18, 1979·The New England Journal of Medicine·S A ShelleyJ U Balis
Feb 1, 1987·Archives of Disease in Childhood·J FrancoualR Leluc
Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter
Apr 1, 1983·The Journal of Pediatrics·S L GoldmanE Bancalari
May 1, 1983·Pediatric Research·R J RobertsJ R Bucher
Oct 1, 1982·American Journal of Diseases of Children·A L CoatesM B Nogrady
Jan 1, 1982·Respiration; International Review of Thoracic Diseases·G SimbrunerH Salzer

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Citations

Aug 1, 1992·European Journal of Pediatrics·P A StevensM Obladen
Jul 21, 2006·The Cochrane Database of Systematic Reviews·L P BrionW Yong

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