PMID: 7542024May 1, 1995Paper

Lectin and immunohistochemical comparison of glycoconjugates in the conjunctiva of patients with and without exfoliation syndrome

The British Journal of Ophthalmology
J HietanenT Kivelä

Abstract

AIMS--The study was carried out to search for labelling similar to that of intraocular exfoliation material in the conjunctiva by light microscopy using lectin and immunohistochemistry. METHODS--Ten formalin fixed and paraffin embedded conjunctival biopsy specimens both from patients with and without exfoliation syndrome were studied with a panel of 11 lectins and with three monoclonal antibodies to the HNK-1 carbohydrate epitope, all of which react with intraocular exfoliation material. RESULTS--The lectin binding profile was essentially the same in specimens from patients with and without exfoliation syndrome. The superficial epithelium reacted similarly with Phaseolus vulgaris (PHA-E), Caragana arborescens (CAA), Helix pomatia (HPA), concanavalin A (ConA), and wheat germ (WGA) agglutinins. Binding was also detected with peanut (PNA) and Bauhinia purpurea (BPA) agglutinins, particularly in patients with exfoliation. The basement membrane generally reacted with Ricinus communis (RCA-I), PHA-E, Vicia villosa (VVA), ConA, and Lens culinaris (LCA) agglutinins. The stroma was weakly labelled with RCA-I, PHA-E, ConA, and LCA. Lectin binding to the vascular endothelium was moderate with RCA-I, PHA-E, CAA, ConA, LCA, and WGA. Inconsi...Continue Reading

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Citations

Jan 1, 1997·Pathology Oncology Research : POR·Marita Uusitalo, Tero Kivelä
Feb 13, 2001·Survey of Ophthalmology·R Ritch, U Schlötzer-Schrehardt
Nov 9, 2000·Progress in Retinal and Eye Research·M Uusitalo, T Kivelä
Apr 5, 2000·Progress in Retinal and Eye Research·E Vesti, T Kivelä
Aug 1, 1996·Australian and New Zealand Journal of Ophthalmology·W E Gillies, A M Brooks
Aug 20, 2015·EBioMedicine·Jon Klokk SlettedalAmund Ringvold
Mar 30, 2018·Journal of Glaucoma·Tero T Kivelä
Oct 3, 2014·Journal of Glaucoma·Margaret E HuflejtMarko I Vuskovic

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