Lectin cytochemical evaluation of somatosensory neurons and their peripheral and central processes in rat and man

Cell and Tissue Research
F NakagawaS S Spicer

Abstract

Paraffin sections of the trigeminal nerve root of the rat, and human spinal nerve root and trigeminal ganglion were stained with a battery of lectin-horseradish peroxidase conjugates to localize and characterize glycoconjugate (GC) in situ. In the rat the myelin sheath of the peripheral segment contained GC with sialic acid most probably linked to the penultinate disaccharide galactose-(beta 1----4)-N-acetylglucosamine (Gal(beta 1----)-GlcNAc), and complex type N-glycosidic side chains. The myelin sheath in the central segment differed in containing little if any of the GC named above and in containing GC with terminal beta-Gal linked to N-acetylgalactosamine (GalNAc), terminal GalNAc and fucose. Schwann cells stained for GC with GlcNAc or mannose whereas oligodendroglia stained for GC with the terminal disaccharide Gal-(beta 1----3)-GalNAc and N-glycosidic side chains, especially in presumed Golgi zones, but also in processes continued as the outer myelin sheath. The human myelin sheath in the central segment differed from that of the rat in not staining with lectins specific for fucose and terminal GalNAc. Sialic acid and terminal beta-Gal were seen in the human central segment but these sugars appeared to bind to astroglial ...Continue Reading

Citations

Oct 1, 1992·Neuroscience Research·S KusunokiI Kanazawa
Jan 1, 1991·Progress in Histochemistry and Cytochemistry·H J Gabius, A Bardosi
Dec 9, 2004·Chemical Reviews·Raz Jelinek, Sofiya Kolusheva
Feb 22, 1990·The Journal of Comparative Neurology·J D Silverman, L Kruger

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