PMID: 9437665Jan 23, 1998Paper

Lectin histochemistry of the rat brain following thioacetamide-induced hepatic failure

Molecular and Chemical Neuropathology
G Szumanska, J Albrecht

Abstract

Biotinyl derivatives of several lectins were used to study the localization of glycoconjugates in the cerebral microcapillaries and various brains of rats given at 24-h intervals two i.p. administrations of a hepatotoxin-thioacetamide (TAA) and examined 21 d posttreatment. At this time, the rats were asymptomatic with regard to hepatic encephalopathy but showed specific and selective changes in the blood-brain-barrier (BBB) transport of basic amino acid, but no BBB damage, and region-specific neuronal injury in the hippocampus and neocortex. The lectins tested recognized the following sugar residues: beta-D-galactosyl (Ricinus communis agglutinin [RCA-1]); N-acetyl-glucosaminyl and N-acetyl-neuraminic acid (wheat-germ agglutinin [WGA]); N-acetyl-D-galactosaminyl (Helix pomatia agglutinin [HPA]); beta-D-galactosyl and D-galactosyl neuraminic acid (peanut agglutinin [PNA]), and alpha-D-galactosyl and alpha-D-mannosyl (concanavalin A [Con A]). The treatment markedly decreased the binding to the cerebromicrovascular network of the hippocampus and neocortex of RCA-1 and WGA. The binding of these two lectins to their complementary monosaccharide residues appears to reflect subtle changes in BBB function, with a detection threshold be...Continue Reading

References

Jan 1, 1987·Acta Neuropathologica·G SzumanskaH M Wisniewski
Jan 1, 1988·Progress in Histochemistry and Cytochemistry·A W Vorbrodt
Feb 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A W VorbrodtH M Wisniewski
Jan 1, 1986·Acta Neuropathologica·G SzumanskaH M Wisniewski
May 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B A Schulte, S S Spicer
Jan 1, 1984·Histochemistry·K SchwechheimerP Möller
Jul 1, 1996·Journal of Neuroscience Research·W HilgierJ Albrecht

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Citations

Jul 5, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·D Fischer, T Kissel
Dec 11, 2013·Neurobiology of Disease·Kakulavarapu V Rama RaoMichael D Norenberg
Feb 26, 2014·Metabolic Brain Disease·Kakulavarapu V Rama RaoMichael D Norenberg
Oct 24, 2020·International Journal of Molecular Sciences·Anna Maria CzarneckaMagdalena Zielińska

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