PMID: 6408485Jul 7, 1983Paper

Lectin-induced expression of DR antigen on human cultured follicular thyroid cells

Nature
R Pujol-BorrellG F Bottazzo

Abstract

HLA-DR antigens, the human equivalent of mouse I region-associated or Ia products, are polymorphic cell surface sialoglycoproteins involved in initiation of the immune response. Their expression is normally restricted to B lymphocytes, macrophages, dendritic and other antigen-presenting cells and vascular endothelium and possibly some cells of the mucosa lining body cavities. HLA-DR expression can be modified during cell differentiation; B lymphocytes become negative on maturing to plasma cells and human T lymphocytes acquire these antigens when activated in vitro or in vivo. We report here that human thyroid follicular cells which are normally negative for HLA-DR molecules, can be induced to express these antigens when cultured with phytohaemagglutinin (PHA), concanavalin A (Con A) or pokeweed mitogen (PWM). These lectins exert their action directly on the thyroid cells with no concomitant mitogenic effect.

References

Jan 1, 1979·Immunological Reviews·F M BrodskyW F Bodmer
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D J Charron, H O McDevitt
Dec 1, 1982·The Journal of Experimental Medicine·A N Barclay, D W Mason
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J S Pober, M A Gimbrone
Dec 1, 1980·European Journal of Immunology·L KlareskogP A Peterson
Jan 1, 1981·Transplantation·P G NataliS Ferrone
Dec 1, 1982·Immunology Today·D F NixonJ A Frelinger
Jan 1, 1983·Immunology Today·J KappB Schwartz

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Citations

Jan 1, 1988·Rheumatology International·P YouinouP Angelidis
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·C S PapadimitriouH M Moutsopoulos
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·J B MatthewsS S Prime
Jan 1, 1990·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H HelbigA G Palestine
Jan 1, 1986·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P YouinouC Ferec
Dec 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·U K EhmannW D Peterson
Jan 1, 1990·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C BaudouinP Lapalus
Jan 1, 1986·Immunologic Research·A P Weetman
Jan 1, 1986·Immunologic Research·G W CanonicaY M Kong
Sep 1, 1986·Cellular Immunology·S T JuM E Dorf
May 1, 1987·Immunology Letters·E BodolayN R Farid
Dec 1, 1987·Immunology Letters·G WickK Hála
Jan 1, 1987·Immunology Today·J J RémyJ Charreire
Oct 1, 1988·Immunology Today·R Pujol-Borrell, G F Bottazzo
Oct 26, 1985·Lancet·I L Campbell, L C Harrison
Feb 1, 1985·Journal of Neuroimmunology·G H WongJ W Schrader
Mar 27, 2002·Nature Reviews. Immunology·Giorgio Stassi, Ruggero De Maria
May 22, 1986·The New England Journal of Medicine·G S Eisenbarth
Nov 22, 2001·Thyroid : Official Journal of the American Thyroid Association·L J HammondR Mirakian
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·A P Weetman
Feb 26, 1999·Thyroid : Official Journal of the American Thyroid Association·K JungheimP M Schumm-Draeger
Aug 1, 1992·American Journal of Reproductive Immunology : AJRI·M Kurpisz, N Fernandez
Aug 1, 1992·American Journal of Reproductive Immunology : AJRI·N S RoteT W Lyden
Mar 1, 1987·Journal of Clinical Pathology·G B McDonald, D P Jewell
Jan 1, 1997·Journal of Endocrinological Investigation·P FalaschiA Proietti
Jun 1, 1990·Clinical Rheumatology·F C Breedveld, R R De Vries

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