Lectin-like oxidized low-density lipoprotein receptor-1 modulates endothelial apoptosis in obstructive sleep apnea

Chest
Morohunfolu E AkinnusiAli A El-Solh

Abstract

Lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) is the major receptor for oxidized low-density lipoprotein in endothelial cells, and its expression is enhanced in proatherogenic settings. The objective of this study was to investigate the association between LOX-1 in freshly harvested human venous endothelial cells and apoptotic circulating endothelial cells in patients with obstructive sleep apnea (OSA). We conducted a prospective, interventional study of 38 patients with newly diagnosed OSA free of disease and 12 healthy control subjects. Plasma LOX-1 (pLOX-1) levels were measured using a commercially available enzyme-linked immunosorbent assay. Protein expression of LOX-1 was quantified by immunofluorescence in freshly harvested venous endothelial cells before and after 8 weeks of continuous positive airway pressure (CPAP) therapy. Circulating apoptotic endothelial cells (CD146(+), CD45(-), and CD31(1)) were assessed concomitantly by flow cytometry. pLOX-1 levels were higher in subjects with OSA than in control subjects (326.9 ± 267.1 pg/mL and 141.1 ± 138.6 g/mL, respectively; P = .004). Patients with OSA showed a threefold increase in baseline endothelial expression of LOX-1 relative to control subjects. CP...Continue Reading

References

May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·C P WeinerS Moncada
Apr 1, 1993·The American Review of Respiratory Disease·N B KribbsD F Dinges
Aug 15, 1998·Biochemical and Biophysical Research Communications·J L Mehta, D Y Li
Mar 11, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·T MuraseT Kita
Jul 17, 2001·Journal of Internal Medicine·K Jensen-Urstad, J Johansson
Aug 17, 2001·Current Opinion in Lipidology·N Kume, T Kita
Dec 12, 2001·Biochemical and Biophysical Research Communications·J L MehtaF Romeo
Feb 14, 2002·Journal of Applied Physiology·Paolo C ColomboThierry H Le Jemtel
May 20, 2005·American Journal of Respiratory and Critical Care Medicine·Luciano F DragerGeraldo Lorenzi-Filho
Jul 5, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Maija BadeauMatti J Tikkanen
Dec 31, 2005·Atherosclerosis·Hiroyuki TanigawaKeijiro Saku
Feb 3, 2007·American Journal of Respiratory and Critical Care Medicine·Ali A El SolhCorey R Mankowski
Mar 3, 2007·American Journal of Respiratory and Critical Care Medicine·Vladimir SavranskyVsevolod Y Polotsky
Jun 9, 2007·American Journal of Respiratory and Critical Care Medicine·Luciano F DragerGeraldo Filho Lorenzi
Dec 21, 2007·The Biochemical Journal·Sarah DunnSreenivasan Ponnambalam
Apr 15, 2008·Journal of Lipid Research·Kathryn C B TanRichard Bucala
Jun 2, 2009·The European Respiratory Journal·L Lavie, P Lavie
Jan 23, 2010·Clinical Chemistry·Nobutaka InoueTatsuya Sawamura

❮ Previous
Next ❯

Citations

Dec 15, 2012·Sleep & Breathing = Schlaf & Atmung·Morohunfolu AkinnusiAli A El-Solh
Aug 7, 2014·Current Hypertension Reports·Meghna P MansukhaniVirend K Somers
Jun 7, 2012·Chest·Mario Francesco DamianiOnofrio Resta
Apr 1, 2015·Genetic Testing and Molecular Biomarkers·Chun-Yan XuGuo-Qiang Ding
Jan 1, 2014·Hypertension·Tomas KonecnyVirend K Somers
Feb 20, 2019·Hypertension·Meghna P MansukhaniVirend K Somers
Dec 1, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·João Pedro FerreiraFaiez Zannad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Annual Review of Medicine
Aarif Y Khakoo, Toren Finkel
Postgraduate Medical Journal
Z S NedeljkovicJ Loscalzo
Arteriosclerosis, Thrombosis, and Vascular Biology
Mihail HristovPeter C Weber
American Journal of Respiratory and Critical Care Medicine
K ChinK Kuno
© 2022 Meta ULC. All rights reserved