Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis

Scandinavian Journal of Rheumatology
K HashimotoMasao Akagi

Abstract

The lectin-like oxidized low density lipoprotein (ox-LDL) receptor 1 (LOX-1)/ox-LDL system, which contributes to the pathogenesis of atherosclerosis, may be involved in the development of osteoarthritis (OA). However, the mechanisms by which the LOX-1/ox-LDL system contributes to OA development in vivo are unclear. In this study, we investigated the direct involvement of LOX-1/ox-LDL in OA development by using LOX-1-knockout (LOX-1(-)/(-)) mice in a joint instability-induced model of OA. OA development was evaluated with histological scoring at 4 and 8 weeks after surgery to induce knee destabilization in LOX-1(+)/(+) and LOX-1(-)/(-) mice. Immunohistological analysis was used to evaluate the expression of LOX-1, ox-LDL, Runt-related transcription factor 2 (Runx2), and type X collagen (COL X) in articular chondrocytes and osteophyte-forming cells. In addition, double immunofluorescence staining was performed to determine the relationships between LOX-1 and Runx2 or COL X expression. In the model of knee destabilization, symptoms were significantly suppressed in LOX-1(-)/(-) mice. LOX-1, ox-LDL, Runx2, and COL X were overexpressed in articular chondrocytes and osteophyte-forming cells in LOX-1(+)/(+) mice and were significantly ...Continue Reading

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Citations

Jan 11, 2017·Current Opinion in Rheumatology·Alice CourtiesFrancis Berenbaum
Oct 4, 2019·European Journal of Immunology·Kazuya ToneGordon D Brown
Dec 13, 2019·Diabetes/metabolism Research and Reviews·Francesca CannataPaolo Pozzilli
Apr 5, 2018·Frontiers in Bioengineering and Biotechnology·Ellen G J RipmeesterTim J M Welting
Jun 20, 2020·The Journal of International Medical Research·Kazuhiko Hashimoto, Masao Akagi
Oct 30, 2019·Physiological Reports·Baraa K Al-KhazrajiJoel Kevin Shoemaker

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