Lectin reactivity of alpha-fetoprotein in a case of renal cell carcinoma.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
K TaketaH Hirai

Abstract

The increased serum level of alpha-fetoprotein (AFP) in a case of renal cell carcinoma, a rare condition of AFP production by mesoderm-derived cells, was evaluated for its lectin reactivity by affinity electrophoresis, followed by the antibody-affinity transfer to nitrocellulose membranes for visualization of separated AFP bands. The AFP of this case was characterized by relative increases of concanavalin A-nonreactive AFP-C1 (60.4%), erythroagglutinating phytohemagglutinin-reactive AFP-P4 (37.8%) and AFP-P5 (46.3%) and Allomyrina dichotoma lectin-nonreactive AFP-A1s (66.7%), and by the total absence of lentil lectin-reactive components, AFP-L2 and AFP-L3. Thus, the lectin-reactive pattern of AFP markedly deviated not only from that of cord serum, but also from those of other malignancies and of fetal kidney cells in culture.

Citations

Jun 15, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A A Terentiev, N T Moldogazieva
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J MarrinkH Schraffordt Koops
Dec 3, 2014·Annals of Diagnostic Pathology·Jungweon ShimYong Mee Cho
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Taketa
Sep 13, 1991·Journal of Chromatography·K Taketa
May 14, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yiming ChenWensheng Hu

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