Left anterior cingulate activity predicts intra-individual reaction time variability in healthy adults

Neuropsychologia
Beth P JohnsonMark A Bellgrove

Abstract

Within-subject, or intra-individual, variability in reaction time (RT) is increasingly recognised as an important indicator of the efficiency of attentional control, yet there have been few investigations of the neural correlates of trial-to-trial RT variability in healthy adults. We sought to determine the neural correlates of intra-individual RT variability during a go/no-go response inhibition task in 27 healthy, male participants. We found that reduced trial-to-trial RT variability (i.e. greater response stability) was significantly associated with greater activation in the left pregenual anterior cingulate. These results support the role of the left anterior cingulate in the dynamic control of attention and efficient response selection. Greater understanding of intra-individual RT variability and top-down attentional control in healthy adults may help to inform disorders that impact executive/attentional control, such as attention deficit hyperactivity disorder and schizophrenia.

References

Feb 13, 2003·Archives of General Psychiatry·Ronald C KesslerAlan M Zaslavsky
Dec 14, 2004·Journal of Neurophysiology·Jason D ConnollyDouglas P Munoz
Feb 4, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Celine MullinsIan H Robertson
Mar 30, 2005·Brain Research. Cognitive Brain Research·Diana H FishbeinSteven Grant
Feb 8, 2006·Trends in Cognitive Sciences·F Xavier CastellanosRosemary Tannock
Jun 13, 2006·Nature Neuroscience·D H WeissmanM G Woldorff
Jun 30, 2006·Biological Psychiatry·Christoph KleinMartin Peper
Mar 14, 2007·Neuropsychologia·Daniel J SimmondsStewart H Mostofsky
Jul 3, 2007·NeuroImage·Daniel S MarguliesMichael P Milham
Sep 1, 2007·NeuroImage·John Ashburner
May 20, 2008·NeuroImage·Chiang-Shan Ray LiTien-Wen Lee
Dec 23, 2009·Psychology and Aging·Stuart W S MacDonaldLars Bäckman
Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert HesterMark A Bellgrove
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jaime S IdeChiang-shan R Li
Jan 31, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael EstermanSarah K Noonan

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Citations

Mar 24, 2016·Brain Imaging and Behavior·Anita D BarberStewart H Mostofsky
Mar 6, 2017·Annals of the New York Academy of Sciences·Francesca C FortenbaughMichael Esterman
Dec 6, 2019·Developmental Psychobiology·Dienke J BosRebecca M Jones

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