Left Atrial Appendage Ligation and Ablation for Persistent Atrial Fibrillation: The LAALA-AF Registry

JACC. Clinical Electrophysiology
Dhanunjaya LakkireddyYeruva Madhu Reddy

Abstract

This study was intended to evaluate the impact of adding the left atrial appendage (LAA) closure system (LARIAT) procedure to conventional atrial fibrillation (AF) ablation in patients with persistent AF. Percutaneous endoepicardial LARIAT may result in both mechanical and electrical exclusion of the LAA and aid in improving the outcomes of catheter ablation by eradicating the LAA triggers and altering the substrate. We performed a prospective observational study of patients with persistent AF referred for AF ablation. Patients underwent LAA ligation with LARIAT procedure before undergoing AF ablation (LARIAT group). Age- and sex-matched persistent AF patients undergoing AF ablation during the same time frame were included in the control group (ablation-only group). A total of 138 patients were included in the study, with 69 patients in the LARIAT group. The mean age of the population was 67 ± 10 years, with 96 (70%) men. Left atrial (LA) size, CHADS2, CHADSVasc, and HAS-BLED scores were higher in the LARIAT group when compared with the ablation-only group. There were no differences in the type of lesions during AF ablation between the groups. The primary outcome of freedom from AF at 1 year off antiarrhythmic therapy after 1 a...Continue Reading

References

May 3, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Takumi YamadaG Neal Kay
Jul 8, 2010·Circulation·Luigi Di BiaseAndrea Natale
Jul 19, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mélèze HociniMichel Haïssaguerre
Sep 22, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Qian YangZi-li Liao
Jun 1, 2012·Interactive Cardiovascular and Thoracic Surgery·Christoph T StarckSacha P Salzberg
Dec 19, 2013·Circulation·Sumeet S ChughChristopher J L Murray
Jan 22, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Frederick T HanRandall J Lee

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Citations

Sep 25, 2017·Journal of Cardiovascular Electrophysiology·Mohit TuragamDhanunjaya Lakkireddy
Nov 11, 2017·Journal of Cardiovascular Electrophysiology·Mohit K Turagam, Dhanunjaya Lakkireddy
Jul 14, 2016·Circulation. Arrhythmia and Electrophysiology·Luigi Di Biase, Andrea Natale
Jun 17, 2020·Expert Review of Medical Devices·Lisette I S WintgensLucas V A Boersma
Aug 8, 2019·Expert Review of Medical Devices·Thiago Guimarães OsórioCarlo De Asmundis
Sep 11, 2020·Current Cardiology Reports·Ghulam MurtazaDhanunjaya Lakkireddy
Jun 9, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas FinkAndreas Metzner
Oct 4, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Nabeela KarimTom Wong
Jul 28, 2017·Clinical Cardiology·Rizma Jalees BajwaRonald D Berger
Oct 18, 2018·Journal of Arrhythmia·Ahmed AlTurkiVidal Essebag
Apr 10, 2019·Pacing and Clinical Electrophysiology : PACE·Stefano BordignonJulian K R Chun
Aug 20, 2016·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Luigi Di Biase, Andrea Natale
Mar 10, 2020·Texas Heart Institute Journal·Payam Safavi-Naeini, Abdi Rasekh
Oct 22, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·José M SanchezRandall J Lee
Dec 17, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jorge RomeroLuigi Di Biase
Feb 19, 2020·Cardiac Electrophysiology Clinics·Krishna AkellaDhanunjaya Lakkireddy
Mar 14, 2021·Indian Pacing and Electrophysiology Journal·Jalaj Garg, Dhanunjaya Lakkireddy
Jun 16, 2021·Circulation. Arrhythmia and Electrophysiology·Rakesh GopinathannairUNKNOWN American Heart Association Electrocardiography and Arrhythmias Committee and Heart Failure and Transplantation Committee of
Jun 5, 2021·Pacing and Clinical Electrophysiology : PACE·Bharat NarasimhanDhanunjaya Lakkireddy
Jun 25, 2021·Journal of Cardiovascular Electrophysiology·Syed Rafay Ali SabzwariDhanunjaya Lakkireddy

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