Left Atrial Appendage Ligation in Nonvalvular Atrial Fibrillation Patients at High Risk for Embolic Events With Ineligibility for Oral Anticoagulation: Initial Report of Clinical Outcomes

JACC. Clinical Electrophysiology
Horst SievertRandall J Lee

Abstract

This study sought to assess long-term clinical outcomes in adults with nonvalvular atrial fibrillation (AF) who are ineligible for oral anticoagulation therapy and underwent left atrial appendage (LAA) ligation with the Lariat device. LAA exclusion has been used to prevent thrombus formation within the LAA in AF patients and is believed to decrease the risk of cardioembolic events. LAA ligation with the Lariat device was performed in 139 patients with nonvalvular AF. LAA closure was verified during the procedure by LA angiography and transesophageal echocardiography. A follow-up transesophageal echocardiography was performed at 30 to 45 days post-procedure. After the procedure, patients received aspirin only, clopidogrel only, aspirin plus clopidogrel, or no antithrombotic drugs. Patients did not receive transition oral anticoagulation therapy post-LAA ligation. Patients were followed for LAA closure and adverse events, including stroke, systemic events, and death. Acute closure was accomplished in 138 of 139 treated patients (99%). In 1 patient, a posterior lobe was partially closed. At the day-30 to day-45 transesophageal echocardiography (n = 127), 114 (90%) had complete LAA closure, and 13 (10%) had a 2- to 4-mm leak. There...Continue Reading

References

Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Aug 1, 1995·Stroke; a Journal of Cerebral Circulation·R G HartD C Anderson
Feb 1, 1996·The Annals of Thoracic Surgery·J A OdellT A Orszulak
May 7, 1998·Circulation·R S Stafford, D E Singer
Mar 10, 2001·Stroke; a Journal of Cerebral Circulation·R G Hart, J L Halperin
Jun 13, 2001·JAMA : the Journal of the American Medical Association·B F GageM J Radford
Jul 24, 2002·Neurology·S E VermeerG J E Rinkel
Jun 14, 2003·Stroke; a Journal of Cerebral Circulation·Mark H EckmanSteven M Greenberg
Dec 12, 2003·The Annals of Thoracic Surgery·Pierre Yves PennecJean Aubert Barra
Aug 7, 2007·The American Journal of Medicine·Margaret C FangDaniel E Singer
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Oct 22, 2010·The New England Journal of Medicine·Martin B LeonUNKNOWN PARTNER Trial Investigators
Feb 12, 2011·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN AVERROES Steering Committee and Investigators
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Jun 15, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Diana StoneAshish Pershad
Oct 12, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Wen-Loong YeowSaibal Kar
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
Jan 22, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Frederick T HanRandall J Lee
Jan 28, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jayanthi N KoneruRandall J Lee
Jul 6, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Anand M PillaiDhanunjaya Lakkireddy
Jul 30, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Marc A MillerVivek Y Reddy
Aug 12, 2014·Journal of the American College of Cardiology·Matthew J PriceMiguel Valderrábano
Aug 21, 2014·Circulation. Arrhythmia and Electrophysiology·Krzysztof BartusRandall J Lee
Nov 17, 2014·JAMA : the Journal of the American Medical Association·Vivek Y ReddyUNKNOWN PROTECT AF Steering Committee and Investigators
Apr 18, 2015·Journal of the American College of Cardiology·Dhanunjaya LakkireddyYeruva Madhu Reddy
Jun 14, 2015·Expert Review of Cardiovascular Therapy·Duong LeRandall J Lee

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Citations

Sep 25, 2017·Journal of Cardiovascular Electrophysiology·Mohit TuragamDhanunjaya Lakkireddy
Sep 3, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Michael GliksonBernhard Meier
Sep 11, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michael GliksonUNKNOWN ESC Scientific Document Group
Feb 12, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Roland Richard TilzKarl-Heinz Kuck
Aug 23, 2016·Texas Heart Institute Journal·Payam Safavi-Naeini, Abdi Rasekh
Sep 29, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Alexander C PerinoMintu P Turakhia
Aug 4, 2018·Texas Heart Institute Journal·Payam Safavi-Naeini, Abdi Rasekh
Jun 9, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas FinkAndreas Metzner
May 10, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Jens Erik Nielsen-KudskDerk W Krieger
Oct 22, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·José M SanchezRandall J Lee
Nov 5, 2020·Journal of Cardiovascular Electrophysiology·Radoslaw LitwinowiczKrzysztof Bartus
Jun 25, 2021·Journal of Cardiovascular Electrophysiology·Syed Rafay Ali SabzwariDhanunjaya Lakkireddy

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