Left atrial coronary perfusion territories in isolated sheep hearts: implications for atrial fibrillation maintenance.

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Masatoshi YamazakiJérôme Kalifa

Abstract

The role of coronary perfusion in the maintenance of atrial fibrillation (AF) electrical sources that anchor to the posterior (wall of the) left atrium (PLA) has been incompletely investigated. We hypothesized that the PLA-pulmonary vein region is perfused by branches originating from both the right and left coronary arteries. The purpose of this study was to evaluate whether branches originating from the right and left coronary arteries could serve as conduits to chemically ablate restricted PLA regions. In Langendorff-perfused sheep hearts, the right anterior and left anterior atrial arteries (RAAA and LAAA) and the branches of the left circumflex artery (LCX) were identified as main coronary artery branches perfusing the atria. During sustained AF, 20-mL boluses of cold Tyrode's solution (4°C) was injected into each artery to determine changes in dominant frequency. The injection that yielded the largest dominant frequency decrease indicated the coronary branch to be subsequently perfused with ethanol. Ethanol was selectively injected into the LAAA (n = 4), LCX (n = 4), or RAAA (n = 1). Six of nine AF cases rapidly terminated upon ethanol perfusion. In those hearts and in eight additional preparations (n = 17), Congo red and...Continue Reading

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Jun 30, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masatoshi YamazakiJérôme Kalifa
Sep 17, 2009·Circulation. Arrhythmia and Electrophysiology·Miguel ValderrábanoDirar S Khoury
Sep 30, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Miguel ValderrábanoDirar S Khoury

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Citations

Mar 5, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masatoshi YamazakiJérôme Kalifa
May 7, 2016·Circulation·Jesús Álvarez-GarcíaJuan Cinca
Jul 23, 2013·Circulation. Arrhythmia and Electrophysiology·Muayad AlasadyPrashanthan Sanders
May 30, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·José M Montero CabezasVictoria Delgado
May 30, 2021·Current Cardiology Reports·Xiao-Dong ZhangNipavan Chiamvimonvat

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