Left atrial fibrosis correlates with extent of left ventricular myocardial delayed enhancement and left ventricular strain in hypertrophic cardiomyopathy

The International Journal of Cardiovascular Imaging
Syed R LatifLauren A Baldassarre

Abstract

Hypertrophic cardiomyopathy (HCM) is associated with increased left ventricular (LV) mass, decreased myocardial strain, and the presence of LV fibrosis and scar. The relationship between LV scar and fibrosis with left atrial (LA) fibrosis in the setting of HCM has not been examined. The purpose of this study is to demonstrate a correlation between the degree of LA fibrosis and LV parameters in subjects with HCM. Twenty-eight subjects with HCM were imaged on a 1.5T MRI scanner with cine, LV and LA late gadolinium enhancement (LGE) sequences. LA LGE and LA measurements were correlated with LV measurements of volumes, mass, strain, and LGE. Other clinical conditions and medication usage were also examined and evaluated for correlation with LA and LV parameters. LV LGE was identified in 24 (86%) of the cases and LA LGE was identified in all of the cases. Extent of LA fibrosis significantly correlated with percent LV LGE (r = 0.64, p = 0.001), but not with indexed LV mass or maximum wall thickness. Extent of LA fibrosis also moderately correlated with decreased LV global strain (radial, r = - 0.50, p = 0.013; circumferential, r = 0.47, p = 0.02; longitudinal, r = 0.52, p = 0.013). Increased LA systolic volume correlated moderately w...Continue Reading

References

Jul 1, 1991·Circulation Research·W CarverL Terracio
Sep 4, 2003·Circulation·Raffaella LombardiMassimo Chiariello
Oct 4, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Hua YangHarry Rakowski
May 3, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·John V WylieThomas H Hauser
Aug 9, 2008·Journal of the American College of Cardiology·Nathaniel Reichek, Dipti Gupta
Nov 5, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Thomas H HauserWarren J Manning
Nov 11, 2008·The American Journal of Cardiology·Barry J MaronEugene Braunwald
Dec 2, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Zoran B PopovićMilind Y Desai
Jan 10, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Maria-Angela LosiMassimo Chiariello
Feb 25, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Irene SavelievaA John Camm
Nov 19, 2011·JACC. Cardiovascular Imaging·Giovanni QuartaJames C Moon
Dec 24, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Rashed KarimKawal Rhode
Feb 6, 2014·JAMA : the Journal of the American Medical Association·Nassir F MarroucheJohannes Brachmann
Jan 7, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangJens-Uwe Voigt
Oct 29, 2015·European Heart Journal·Otto A SmisethStig Urheim
Feb 14, 2016·European Heart Journal Cardiovascular Imaging·Trine F HalandKristina H Haugaa
Apr 18, 2016·JACC. Cardiovascular Imaging·Dana C PetersSudhakar Chelikani
Jul 28, 2016·JACC. Cardiovascular Imaging·Zhen WengYang He
Aug 27, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Gianni PedrizzettiEike Nagel
Feb 12, 2017·Circulation. Arrhythmia and Electrophysiology·Philippe DebonnaireNina Ajmone Marsan
Dec 30, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Hoshang FarhadTomas G Neilan
Apr 20, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·J Jane CaoQizhi Chen
Jan 4, 2019·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Michael QuailDana C Peters

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Citations

Apr 3, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Anna HohneckTheano Papavassiliu
Apr 14, 2020·The International Journal of Cardiovascular Imaging·Johan H C ReiberJoachim Lotz

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