Left atrial thrombus in patients with atrial fibrillation and under oral anticoagulant therapy; 3-D transesophageal echocardiographic study

The International Journal of Cardiovascular Imaging
Eser DurmazZeki Ongen

Abstract

Ischemic stroke is the major complication of atrial fibrillation (AF) and only proven preventive therapy is oral anticoagulant therapy (OAC). Previous studies reported the presence of thrombus in the left atrium (LA) or left atrial appendage (LAA) despite anticoagulant therapy. We aim to investigate the predictors of LA/LAA thrombus in patients under OAC therapy and long-term clinical impact of thrombus. We prospectively enrolled consecutive patients with permanent AF under OAC therapy. Patients baseline characteristics were recorded. Transesophageal echocardiographic study performed after complete transthoracic echocardiographic study. 3-D evaluation of LAA was made using 3-D zoom mode and thrombus was defined when echo reflecting, mobile mass detected. Patients clinical outcomes were decided according to hospital records or via phone calls. Among 184 patients, 28 LAT were detected. Mean CHA2DS2-VASc score was significantly higher in patients with LAT in comparison to patients without LAT. CHA2DS2-VASc score (p: 0.001), left atrial volume (p: 0.001), left atrial flow velocity (p: 0.006) and left ventricular ejection fraction (p: 0.014) were independently associated with LAT. Among the parameters in CHA2DS2-VASc score, the prev...Continue Reading

References

Apr 2, 2011·Stroke; a Journal of Cerebral Circulation·Keerthi M MohanAndrew P Grieve
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·T Nightingale, D Cutler
Aug 26, 2015·Stroke; a Journal of Cerebral Circulation·Søren Due AndersenTorben Bjerregaard Larsen
Jan 15, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Muhamed SaricKirsten Tolstrup

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