Left atrial volume provides independent prognostic value in patients with Chagas cardiomyopathy

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Maria Carmo P NunesManoel O C Rocha

Abstract

Heart failure is a severe clinical manifestation of Chagas disease. Left atrial volume (LAV), a marker of chronically elevated left ventricular (LV) filling pressure, is a predictor of prognosis in patients with heart failure and may be important in the assessment of risk in patients with Chagas disease. The aim of this study was to identify echocardiographic parameters of diastolic function predictors of survival in patients with Chagas cardiomyopathy. A total of 192 patients with Chagas cardiomyopathy (mean age, 48.5 +/- 12.1 years; 37% women) were prospectively enrolled. The end points were death and cardiac transplantation. Over a mean follow-up period of 33.8 months, LAV normalized for body surface area emerged as an independent predictor of survival (hazard ratio, 1.037 per 1 mL/m(2) change; 95% confidence interval, 1.018-1.056; P < .001), adding incremental prognostic value to clinical factors, LV ejection fraction, and Doppler-derived parameters of diastolic function. Receiver operating characteristic curve analysis identified the best cutoff values for the prediction of end points. LAV > 51 mL/m(2) was associated with significant excess mortality (log-rank, P < .001). LAV provides powerful prognostic information increm...Continue Reading

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Citations

Sep 24, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Cesar Augusto S NascimentoRoberto M Saraiva
Aug 28, 2012·Revista Española De Cardiología·Marcia M Barbosa, Maria Carmo P Nunes
Feb 7, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Maria Pereira NunesManoel Otávio Rocha
Mar 1, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Frederico J N MancusoOrlando Campos
Jan 5, 2011·International Journal of Cardiology·Maria Carmo P NunesManoel O C Rocha
Jan 30, 2010·Progress in Cardiovascular Diseases·Andréia BioloNadine Clausell
Nov 3, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Woo-In YangJong-Won Ha
Apr 24, 2010·Echocardiography·Marcia Maria Oliveira LimaAntônio Luiz P Ribeiro
Sep 6, 2011·The American Journal of Cardiology·Jeonggeun MoonSeung-Yun Cho
Sep 27, 2015·Global Heart·Maria Carmo P NunesManoel Otávio da Costa Rocha
Dec 3, 2013·Journal of the American College of Cardiology·Brian D Hoit
Jun 19, 2013·Journal of the American College of Cardiology·Maria Carmo Pereira NunesUNKNOWN Council on Chagas Disease of the Interamerican Society of Cardiology
Dec 14, 2011·Archives of Cardiovascular Diseases·Dania MohtyArnaud Jaccard
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Manoel Otávio C RochaAntonio L Ribeiro
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Anis RassiJosé Antonio Marin-Neto
Nov 4, 2017·The International Journal of Cardiovascular Imaging·Frederico J N MancusoOrlando Campos
Oct 27, 2012·Expert Review of Cardiovascular Therapy·Maria Carmo Pereira NunesAntonio Luiz Ribeiro
Aug 1, 2012·Nature Reviews. Cardiology·Antonio L RibeiroManoel O C Rocha
Jul 18, 2014·Current Opinion in Cardiology·Fang FangCheuk-Man Yu
Jul 21, 2011·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Marcia M BarbosaMaria Carmo Pereira Nunes
Oct 26, 2018·Circulation·Maria Carmo Pereira NunesUNKNOWN American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Cardiovascular Dis
Nov 6, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Marco Antonio Prates NielebockRoberto Magalhães Saraiva
May 1, 2021·Pathogens·Antonia Pino-MarínHector M Medina

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