Left bundle branch block-induced left ventricular remodeling and its potential for reverse remodeling

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
Edward Sze, James P Daubert

Abstract

With the emergence of cardiac resynchronization therapy (CRT) as a powerful tool to reverse left ventricular dysfunction in patients with left bundle branch block (LBBB), there is increasing awareness that LBBB-induced dyssynchrony may be a primary cause of heart failure with reduced ejection fraction (HFrEF). Current guidelines for implanting CRT require at least 3 months of guideline-directed medical therapy (GDMT) before device implantation in the hopes that medications will reverse cardiomyopathy and obviate the need for device therapy. However, no randomized controlled trial demonstrating efficacy of medications ever stratified outcomes by patients with conduction abnormalities. Consequently, CRT, not GDMT, may be a more effective first-line therapy for patients with LBBB and HFrEF. This review evaluates the evidence for LBBB-induced cardiomyopathy, examines the rationale for GDMT in this population, and presents the evidence for direct implantation of CRT. It is likely that many patients would benefit from earlier intervention with CRT, though about 25% of patients with LBBB and HFrEF may respond to GDMT.

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Citations

May 30, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Eleonora MocciaGuido Parodi
Mar 19, 2020·Circulation. Arrhythmia and Electrophysiology·Nicholas Y TanYong-Mei Cha
Apr 1, 2020·International Heart Journal·Hisataka Maki, Norihiko Takeda
Nov 13, 2020·European Journal of Heart Failure·Kevin Vernooy, Hans-Peter Brunner-La Rocca
Apr 19, 2021·JACC. Cardiovascular Imaging·Simon CalleFrank Timmermans
Jun 21, 2021·JACC. Cardiovascular Imaging·Ole J SlettenHelge Skulstad
Jul 15, 2021·Journal of Cardiovascular Medicine·Sam StrawKlaus K Witte

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