Left Heart Dysfunction in Acromegaly Revealed by Novel Echocardiographic Methods.

Frontiers in Endocrinology
Beata Uziȩbło-ŻyczkowskaPaweł Krzesiński

Abstract

Background: Acromegaly is a rare disease that requires modern treatment to decrease the risk of mortality, mainly from vascular diseases. Identifying acromegalic patients with increased cardiovascular risk is challenging. Speckle-tracking echocardiography (STE) is a modern, well-validated, and reproducible method of assessing left ventricular longitudinal deformation and providing a sensitive assessment of myocardial contractility. We hypothesized that STE may be useful in evaluating subclinical dysfunction of the left heart in acromegalic patients, especially when a left ventricle (LV) assessment is completed with STE of the left atrium (LA). Purpose: To assess the diagnostic value of speckle-tracking echocardiography in identifying the occurrence of LV and LA functional impairment in patients with acromegaly, in comparison to patients without this rare pituitary disease. Methods: Echocardiographic assessments of LV and LA function using the new STE method were performed in 60 subjects: 30 acromegalic (ACRO group) patients and a CONTROL group with 30 patients matched in terms of age, gender, systolic/diastolic pressure, and history of hypertension for at least 12 months. Results: The ACRO group, compared to the CONTROL group, ...Continue Reading

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Citations

Apr 20, 2021·Frontiers in Oncology·Han YangJianwei Li
Oct 31, 2021·Journal of Clinical Ultrasound : JCU·Beata Uziębło-ŻyczkowskaGrzegorz Gielerak

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pharmacotherapy

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