Left heart pressures can be the key to know the limitation of left ventricular assist device support against progression of aortic insufficiency

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
Kei IizukaEisuke Tatsumi

Abstract

Aortic insufficiency (AI) is a worrisome complication under left ventricular assist device (LVAD) support. AI progression causes LVAD-left ventricular (LV) recirculation and can require surgical intervention to the aortic valve. However, the limitations of LVAD support are not well known. Using an animal model of LVAD with AI, the effect of AI progression on hemodynamics and myocardial oxygen metabolism were investigated. Five goats (Saanen 48 ± 2 kg) underwent centrifugal type LVAD, EVAHEART, implantation. The AI model was established by placing a vena cava filter in the aortic valve. Cardiac dysfunction was induced by continuous beta-blockade (esmolol) infusion. Hemodynamic values and myocardial oxygen extraction ratio (O2ER) were evaluated while changing the degree of AI which was expressed as the flow rate of LVAD-LV recirculation (recirculation rate). Diastolic aortic pressure was decreased with AI progression and correlated negatively with the recirculation rate (p = 0.00055). Systolic left ventricular pressure (LVP) and mean left atrial pressure (LAP) were increased with AI progression and correlated positively with the recirculation rate (p = 0.010, 0.023, respectively). LVP and LAP showed marked exponential increases w...Continue Reading

References

Dec 14, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Kenji YamazakiHiromi Kurosawa
Feb 7, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Egemen TuzunKamuran A Kadipasaoglu
Jul 14, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sang-Woo PakUlrich P Jorde
Aug 27, 2010·Circulation. Heart Failure·Jennifer CowgerTheodore J Kolias
Jul 30, 2014·The Annals of Thoracic Surgery·Nikhil Prakash PatilAndré Rüdiger Simon
Dec 17, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jennifer CowgerJerry D Estep
Oct 17, 2016·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yoshifumi ItodaMinoru Ono
Apr 22, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kei IizukaEisuke Tatsumi

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Citations

Feb 24, 2019·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Y SawaT Yamaoka
Jul 25, 2018·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kei IizukaEisuke Tatsumi

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