PMID: 9160063May 1, 1997Paper

Left vagus nerve stimulation in children with refractory epilepsy: an update

Southern Medical Journal
G HornigC Tilton

Abstract

This report updates previous reports regarding the tolerance and efficacy of periodic vagus nerve stimulation in a group of 19 children with medically and surgically intractable epilepsy. After vagal stimulator implantation, follow-up continued from 2 months to 30 months, with the study period ending in October 1995. Of the 19 patients, 6 (32%) had more than a 90% reduction in the number of monthly seizures, and 10 (53%) had more than a 50% reduction. Global evaluation scores indicated that only 1 patient had deterioration from baseline, 5 had no change, and the remainder had modest to remarkable improvement. All 3 children with unsuccessful corpuscallosotomy had improvement after implantation of the stimulator, and 5 of 6 children with Lennox-Gastaut syndrome had a 90% reduction of seizures. Five patients required fewer antiepileptic medications, and 1 patient had an increase in medication. Adversities included 2 possible wound infections, 1 instance of generator failure, and hoarseness during stimulation in all patients. Changing stimulation parameters to increase the rate of stimulation and reduce the interval between stimulations resulted in improved seizure control in 4 of 5 patients. Periodic VNS was well tolerated by the...Continue Reading

Citations

May 24, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jeffrey P BlountMartina Bebin
Jul 4, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mony BeniflaElizabeth J Donner
Mar 6, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S M R KabirJ McMullan
Mar 7, 2006·Neurosurgical Review·F RychlickiM Scerrati
Jan 1, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew H MilbyGordon H Baltuch
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew H MilbyGordon H Baltuch
Nov 26, 2002·Clinical Neurology and Neurosurgery·Paolo TanganelliGiovanni Regesta
Mar 20, 2004·Brain & Development·Sabrina BuoniAlberto Fois
May 19, 2001·Neurologic Clinics·J W WhelessC Ghanbari
Dec 18, 2001·Pediatric Neurology·I ValenciaJ J Riviello
Jul 31, 1998·Pediatric Neurology·J V MurphyC L Tilton
Nov 16, 2001·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·H J MajoieW O Renier
May 28, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J P Beekwilder, T Beems
Jan 1, 2010·Neuromodulation : Journal of the International Neuromodulation Society·Won Chul NamgungJung-Kyo Lee
Jan 1, 2000·International Journal of Adolescent Medicine and Health·James J Riviello
Apr 2, 2009·Neuropsychiatric Disease and Treatment·Kenou van Rijckevorsel
Aug 16, 2011·Journal of Neurosurgery·Dario J EnglotKurtis I Auguste
Dec 12, 2012·Surgical Neurology International·Jason S Hauptman, Gary W Mathern
Aug 14, 2012·Pediatric Neurology·Amanda F VanStraten, Yu-Tze Ng
Aug 11, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Sylvia KlinkenbergAlbert P Aldenkamp
Aug 31, 2010·Epilepsy & Behavior : E&B·Muhammad M Abd-El-BarrDaniel Yoshor
Jul 2, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Makram ObeidMohamad A Mikati
May 1, 2012·Developmental Medicine and Child Neurology·Sylvia KlinkenbergMarian Majoie
Mar 1, 2012·Annals of Neurology·Robert S Fisher
Mar 26, 2016·Journal of Neurosurgery. Pediatrics·David RévészElinor Ben-Menachem
Jul 20, 2010·Journal of Pediatric Surgery·David S CoykendallAugusto Morales
Dec 27, 2005·Epilepsy & Behavior : E&B·Evelyn S Tecoma, Vicente J Iragui
Jul 23, 2013·Seizure : the Journal of the British Epilepsy Association·Hannes Kahlow, Magnus Olivecrona
Jan 7, 2003·The Journal of the American Dental Association·Howard W Roberts
Jan 12, 2005·Seizure : the Journal of the British Epilepsy Association·H J M MajoieA G H Kessels
Mar 15, 2006·Seizure : the Journal of the British Epilepsy Association·Marina CasazzaGiovanni Broggi
Jul 29, 2008·Seizure : the Journal of the British Epilepsy Association·E RossignolL Carmant
Dec 24, 2002·Seizure : the Journal of the British Epilepsy Association·Sarah L Farnalls, Janet Rennick
Dec 24, 2002·Seizure : the Journal of the British Epilepsy Association·Karl O NakkenRasmus Lossius
Oct 8, 1999·Seizure : the Journal of the British Epilepsy Association·K VonckJ De Reuck
Nov 12, 2013·Epilepsy & Behavior : E&B·Vera C TerraHelio R Machado
Mar 21, 2002·Acta Neurologica Scandinavica·L NagarajanM Lee
May 3, 2011·Journal of Neurosurgery. Pediatrics·Robert E ElliottWerner K Doyle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.