Left ventricle afterload impedance control by an axial flow ventricular assist device: a potential tool for ventricular recovery

Artificial Organs
Francesco MoscatoHeinrich Schima

Abstract

Ventricular assist devices (VADs) are increasingly used for supporting blood circulation in heart failure patients. To protect or even to restore the myocardial function, a defined loading of the ventricle for training would be important. Therefore, a VAD control strategy was developed that provides an explicitly definable loading condition for the failing ventricle. A mathematical model of the cardiovascular system with an axial flow VAD was used to test the control strategy in the presence of a failing left ventricle, slight physical activity, and a recovering scenario. Furthermore, the proposed control strategy was compared to a conventional constant speed mode during hemodynamic changes (reduced venous return and arterial vasoconstriction). The physiological benefit of the control strategy was manifested by a large increase in the ventricular Frank-Starling reserve and by restoration of normal hemodynamics (5.1 L/min cardiac output at a left atrial pressure of 10 mmHg vs. 4.2 L/min at 21 mmHg in the unassisted case). The control strategy automatically reduced the pump speed in response to reduced venous return and kept the pump flow independent of the vasoconstriction condition. Most importantly, the ventricular load was ke...Continue Reading

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Citations

Mar 16, 2011·Artificial Organs·Paul S Malchesky
May 26, 2012·Artificial Organs·Robert Francis SalamonsenNigel Hamilton Lovell
Jan 1, 2014·Artificial Organs·Nicholas R GaddumRobert Salamonsen
Aug 2, 2013·Artificial Organs·Frank NestlerDaniel L Timms
Oct 10, 2013·Artificial Organs·Marcus GraneggerFrancesco Moscato
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Jul 31, 2012·The Journal of Thoracic and Cardiovascular Surgery·Francesco MoscatoHeinrich Schima
Oct 16, 2015·IEEE Transactions on Bio-medical Engineering·Marcus GraneggerFrancesco Moscato
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Sep 15, 2019·Artificial Organs·Eric L WuShaun D Gregory
Feb 10, 2017·Biomedizinische Technik. Biomedical Engineering·Anastasios PetrouMarianne Schmid Daners
Nov 3, 2017·Artificial Organs·Anastasios PetrouMarianne Schmid Daners
Nov 27, 2020·Frontiers in Physiology·Max HaberbuschFrancesco Moscato
Mar 8, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kaiyun GuFeng Wan
May 29, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Guruprasad A GiridharanSteven C Koenig
May 1, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Bin GaoYoujun Liu
May 12, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Bin GaoYoujun Liu

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