Left ventricular-arterial system coupling at peak exercise in dilated nonischemic cardiomyopathy

Chest
A Cohen-SolalR Gourgon

Abstract

We assessed the ventricular-arterial coupling at peak exercise in 20 patients with dilated cardiomyopathy (ejection fraction, 27+/-12%) and 7 normal subjects by radionuclide ventriculography during exercise, coupled with respiratory gas analysis. The end-systolic pressure-volume ratio, taken as an index of contractility, and the effective arterial elastance were calculated at rest and at peak exercise. The end-systolic pressure/volume ratio increased from 3.7+/-2.7 to 6.9+/-4.0 mm Hg/mL at peak exercise in the normal subjects, but did not change significantly (from 0.9+/-0.5 to 1.0+/-0.6 mm Hg/mL) in the patients. Arterial elastance did not change significantly in the patients (+17+/-32%, not significant [NS] vs rest) or in the normal subjects (+22+/-28%, NS vs rest). The change in ejection fraction during exercise correlated both with the end-systolic pressure/volume ratio and with effective arterial elastance changes (r=0.60 and 0.68, respectively). We conclude that ventricular arterial coupling is further altered at peak exercise in these patients because of the lack of increase in contractility and not of altered effective arterial elastance response.

References

Nov 1, 1977·The American Journal of Cardiology·K SagawaK M Bakalar
Aug 1, 1992·International Journal of Cardiology·H AsanoiS Sasayama
May 1, 1992·Circulation·L A MulieriN R Alpert
Jun 15, 1991·The American Journal of Cardiology·M J SullivanM B Higginbotham
Apr 1, 1990·Journal of the American College of Cardiology·G S RoubinD T Kelly
Aug 1, 1989·Circulation Research·H AsanoiT Kameyama
Feb 1, 1986·Circulation Research·M B HigginbothamF R Cobb
Apr 1, 1985·Journal of the American College of Cardiology·G S FrancisJ N Cohn
Mar 1, 1985·The American Journal of Cardiology·A NitenbergS Zouioueche
May 1, 1984·Circulation Research·W L MaughanK Sagawa
Jan 1, 1983·The American Journal of Cardiology·M B HigginbothamF R Cobb

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Citations

Dec 8, 2005·Current Heart Failure Reports·Justin M Fox, Mathew S Maurer
Mar 12, 2013·Intensive Care Medicine·Sabino ScollettaDaniel De Backer
Jun 5, 2007·Current Cardiology Reports·Justin M Fox, Mathew S Maurer
Jun 3, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Tonino BombardiniDanilo Neglia
May 9, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Darren E R WarburtonMark J Haykowsky
Oct 18, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Paul D ChantlerSamer S Najjar
Jul 9, 2014·Journal of Cardiovascular Medicine·Pier Sergio SabaRoberto Pedrinelli
Oct 14, 2009·The International Journal of Cardiovascular Imaging·Raymond C WongMilind Y Desai
Nov 24, 2011·Heart Failure Clinics·James B Strait, Edward G Lakatta
Sep 5, 2014·European Journal of Clinical Investigation·Emmanuelle BerthelotDamien Logeart
Jul 24, 2015·European Journal of Clinical Investigation·Emre AslangerAlain Cohen-Solal
Sep 11, 2004·Journal of the American College of Cardiology·Samer S NajjarEdward G Lakatta
Jun 19, 2013·Journal of the American College of Cardiology·Bonnie KyThomas P Cappola
Feb 27, 2003·The International Journal of Artificial Organs·M GrigioniV Barbaro
Mar 29, 2018·European Heart Journal Cardiovascular Imaging·Guido ClaessenHein Heidbuchel

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