Left ventricular assist device pump thrombosis: is there a role for glycoprotein IIb/IIIa inhibitors?

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Lavanya BellumkondaPramod Bonde

Abstract

Left ventricular assist devices (LVADs) fill a critical need by providing circulatory support to patients with end-stage heart failure who are either ineligible for heart transplant or too ill to stably wait for an eventual donor organ. Furthermore, they are critical to the arsenal of the heart failure cardiologist, given the supply/demand mismatch for donor organs. Unfortunately, these devices present their own complications. Despite antiplatelet agents and systemic anticoagulation, a number of patients present with pump thrombosis, a life-threatening event requiring either pump exchange or treatment with systemic thrombolytics. In an effort to avoid these morbid therapies, glycogen IIb/IIIa inhibitors, which have both antiplatelet and thrombolytic properties, have been proposed to treat pump thrombosis. We report here the largest case series using these agents and document a previously unreported high failure rate with this therapy.

References

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Citations

Jun 28, 2016·Critical Care : the Official Journal of the Critical Care Forum·Ayan SenJ Christopher Farmer
Dec 17, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Geetanjali DangLisa Baumann Kreuziger
Nov 26, 2015·Journal of Pharmacy Practice·Christina Teeter Doligalski, Douglas L Jennings
Jun 21, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Elizabeth HohnerMichael P Moranville

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