Abstract
In the early stage of diabetes, the cardiac ejection fraction is preserved, despite the existence of the subclinical cardiac dysfunction to some extent. However, the detailed phenotype of this dysfunction and the underlying mechanism remain unclear. To improve our understanding of this issue, we used low-dose STZ and high-fat diet to induce type 2 diabetic models in rats. The effects and the mechanism associated with the early stages of the disease were analyzed. The type 2 diabetic mellitus (T2DM) in SD rats were induced through 30 mg/kg STZ and high-fat diet. Two-dimensional spackle-tracking echocardiography (STE) and the dobutamine test were performed to examine the cardiac function. Calcium transients of left ventricular myocytes were detected and the related intracellular signalling factors were analyzed by western blotting. After 6-weeks, T2DM rats in left ventricular (LV) diastole showed decreased global and segment strain(S) levels (P < 0.05), both in the radial and circumferential directions. Strain rate (Sr) abatement occurred in three segments in the radial and circumferential directions (P < 0.05), and the radial global Sr also decreased (P < 0.05). In the systolic LV, radial Sr was reduced, except the segment of th...Continue Reading
References
Feb 13, 2001·The American Journal of Cardiology·M ZabalgoitiaF A Maklady
Aug 6, 2004·Endocrine Reviews·Zhi You FangThomas H Marwick
Oct 26, 2005·Cardiovascular Toxicology·Patricia M KralikPaul N Epstein
Oct 28, 2005·Cardiovascular Ultrasound·Eric PlanteMarie Arsenault
Apr 14, 2006·Diabetologia·S-Y LiJ Ren
Nov 23, 2006·Journal of the American College of Cardiology·James D Thomas, Zoran B Popović
Jun 27, 2007·Circulation·Sihem Boudina, E Dale Abel
Nov 17, 2007·Cardiovascular Research·An Van den BerghPaul Herijgers
Jan 10, 2009·Experimental Diabetes Research·Ming ZhangLi Chen
Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Zhuo YuHuang-Tian Yang
Sep 4, 2009·Disease Models & Mechanisms·Heiko Bugger, E Dale Abel
Apr 29, 2010·Heart·Hermann Blessberger, Thomas Binder
Jul 9, 2010·The Veterinary Clinics of North America. Small Animal Practice·Valérie Chetboul
Dec 4, 2010·Circulation·Arnold C T NgJeroen J Bax
Jan 5, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Sergio MondilloUNKNOWN Echocardiography Study Group Of The Italian Society Of Cardiology (Rome, Italy)
Nov 10, 2011·Journal of Magnetic Resonance Imaging : JMRI·Grigorios KorosoglouHugo A Katus
Feb 1, 2012·Acta Physiologica·Z MiklósT Ivanics
Apr 12, 2012·The Journal of Biological Chemistry·Benjamin R NixonBrandon J Biesiadecki
Jul 7, 2012·Current Heart Failure Reports·Sandrine HormanLuc Bertrand
Jul 7, 2012·PloS One·Akifumi TakadaTetsuji Miura
Jun 26, 2013·European Heart Journal Cardiovascular Imaging·Cornelis J RoosVictoria Delgado
Aug 21, 2013·Circulation Research·Stephen C KolwiczRong Tian
Jun 28, 2014·European Heart Journal Cardiovascular Imaging·Jamal Nasir KhanGerry Patrick McCann
Oct 9, 2014·BMC Cardiovascular Disorders·Rong-juan LiYi-jia Li
Citations
Sep 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Bing-Yan CaoYue-Ying Wang
Apr 14, 2017·Heart Failure Reviews·Marijana TadicBurket Pieske
Feb 25, 2017·Cardiovascular Diabetology·A Lorenzo-AlmorósÓ Lorenzo
Jun 30, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Guohua LiFeng Gao
Nov 10, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Yin KangBradley B Keller
Apr 13, 2018·Oxidative Medicine and Cellular Longevity·Ola Al-AssiAhmed F El-Yazbi
Jul 2, 2019·Experimental and Therapeutic Medicine·Shuliang TaoYueming Zhang
Feb 3, 2018·Molecular Medicine Reports·Juncheng ZhuoChengzhe Zhang
Dec 17, 2020·European Journal of Clinical Investigation·Ioan-Alexandru MinciunăAngela Cozma
Jul 11, 2021·Bone·Peipei ShiHe Gong
Aug 19, 2020·European Journal of Pharmacology·Abdul HayeManju Sharma