Left ventricular deformation associated with cardiomyocyte Ca(2+) transients delay in early stage of low-dose of STZ and high-fat diet induced type 2 diabetic rats

BMC Cardiovascular Disorders
Xiao-Ying LiuXi-Yong Yu

Abstract

In the early stage of diabetes, the cardiac ejection fraction is preserved, despite the existence of the subclinical cardiac dysfunction to some extent. However, the detailed phenotype of this dysfunction and the underlying mechanism remain unclear. To improve our understanding of this issue, we used low-dose STZ and high-fat diet to induce type 2 diabetic models in rats. The effects and the mechanism associated with the early stages of the disease were analyzed. The type 2 diabetic mellitus (T2DM) in SD rats were induced through 30 mg/kg STZ and high-fat diet. Two-dimensional spackle-tracking echocardiography (STE) and the dobutamine test were performed to examine the cardiac function. Calcium transients of left ventricular myocytes were detected and the related intracellular signalling factors were analyzed by western blotting. After 6-weeks, T2DM rats in left ventricular (LV) diastole showed decreased global and segment strain(S) levels (P < 0.05), both in the radial and circumferential directions. Strain rate (Sr) abatement occurred in three segments in the radial and circumferential directions (P < 0.05), and the radial global Sr also decreased (P < 0.05). In the systolic LV, radial Sr was reduced, except the segment of th...Continue Reading

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Citations

Sep 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Bing-Yan CaoYue-Ying Wang
Feb 25, 2017·Cardiovascular Diabetology·A Lorenzo-AlmorósÓ Lorenzo
Jun 30, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Guohua LiFeng Gao
Nov 10, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Yin KangBradley B Keller
Dec 17, 2020·European Journal of Clinical Investigation·Ioan-Alexandru MinciunăAngela Cozma

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Methods Mentioned

BETA
ELISA
lavage
electrophoresis

Software Mentioned

GraphPad Prism
Vevo Strain

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