Left ventricular diastolic function, assessed by echocardiography and tissue Doppler imaging, is a strong predictor of cardiovascular events, superior to global left ventricular longitudinal strain, in patients with type 2 diabetes

European Heart Journal Cardiovascular Imaging
Peter BlomstrandJan Engvall

Abstract

The aim of the study was to determine whether left ventricular systolic function, in terms of global left ventricular longitudinal strain (GLS), and diastolic function, expressed as the ratio between early diastolic transmitral flow and mitral annular motion velocities (E/e'), can predict cardiovascular events in patients with diabetes mellitus type 2. We prospectively investigated 406 consecutive patients, aged 55-65 years, with diabetes mellitus, who participated in the CARDIPP study. Echocardiography, pulse pressure (pp), and glycosylated haemoglobin (HbA1c) were analysed. Twelve cases of myocardial infarction and seven cases of stroke were identified during the follow-up period of 67 ± 17 months. Univariate Cox regression analysis showed that E/e' was a strong predictor of cardiovascular events (hazards ratio 1.12; 95% confidence interval 1.06-1.18, P < 0.001). E/e' was prospectively associated with cardiovascular events independent of age, sex, GLS, left ventricular ejection fraction (LVEF), pp, and HbA1c in multivariate analysis. Receiver operating characteristic curves showed that E/e' and HbA1c were the strongest predictors for cardiovascular events, both having an area under the curve (AUC) of 0.71 followed by LVEF wit...Continue Reading

References

Oct 1, 1987·Journal of the American College of Cardiology·C Y ChoongM A Fifer
Nov 8, 1972·The American Journal of Cardiology·S RublerA Grishman
Dec 16, 1998·Clinical Cardiology·K S Spector
Mar 27, 2001·Journal of the American College of Cardiology·A M Dart, B A Kingwell
Aug 23, 2003·Journal of the American College of Cardiology·Jeptha P CurtisHarlan M Krumholz
Sep 24, 2004·Annals of Internal Medicine·Elizabeth SelvinSherita Hill Golden
Dec 13, 2005·Coronary Artery Disease·Dimitrios N TziakasJuan Carlos Kaski
Nov 23, 2006·Journal of the American College of Cardiology·James D Thomas, Zoran B Popović
Jun 27, 2007·Circulation·Sihem Boudina, E Dale Abel
Feb 26, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Marjorie Richardson-LobbedezPierre V Ennezat
Apr 26, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·A-B WiréhnJ Carstensen
Sep 9, 2008·The American Journal of Cardiology·Jens M OlsonMahbubul Alam
Nov 15, 2008·Journal of the American College of Cardiology·Leah IlesAndrew J Taylor
Apr 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·E M DahlénC J Ostgren
May 12, 2009·The American Journal of Cardiology·Aaron M FromHorng H Chen
Aug 5, 2009·Circulation·Frank WeidemannJörg M Strotmann
Aug 8, 2009·Journal of the American College of Cardiology·Goo-Yeong ChoDong-Jin Oh
Mar 18, 2010·Circulation. Cardiovascular Imaging·Julien NahumPascal Lim
Sep 3, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Aude MignotStéphane Lafitte
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson

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Citations

Oct 9, 2015·Journal of cardiovascular ultrasound·Hyun Ju YoonJong Chun Park
Apr 19, 2019·Journal of Cardiovascular Development and Disease·Ify R Mordi
Nov 20, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·M SameforsC J Östgren
May 23, 2020·Hormones : International Journal of Endocrinology and Metabolism·Maria SameforsCarl Johan Östgren
Sep 1, 2021·Scientific Reports·Hooman KamelSanjiv Shah

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