PMID: 3383878Apr 1, 1988Paper

Left ventricular diastolic function in young long-term type 1 (insulin-dependent) diabetic men during exercise assessed by digitized echocardiography

European Heart Journal
R DanielsenH Vik-Mo

Abstract

Digitized M-mode echocardiograms were obtained during semisupine bicycle exercise in 10 relatively young (less than 40 years) long-term (greater than or equal to 12 years) type 1 (insulin-dependent) diabetic men, without overt heart disease, and 10 controls. Recordings were done at rest and during workloads of 50 and 100 W. At rest, heart rate was similar in the groups, while at peak exercise it was higher in the diabetics whose left ventricular (LV) end-diastolic dimension was smaller at all study phases. From baseline to peak exercise the diastolic period decreased in both groups, while the LV diastolic peak rate of dimension increase, normalized for end-diastolic dimension, the rapid filling period and the LV dimension change during this period increased. The normalized peak rates of dimension increase and heart rates correlated positively in the groups. However, diabetics had a lower normalized peak rate of dimension increase after adjusting for heart rate by covariance analysis, both at rest (18%) and during peak exercise (20%). Thus, compared to controls, this well defined group of type 1 diabetic men had a consistent subclinical decrease in their peak rate of dimension increase, both at rest and during exercise. Furtherm...Continue Reading

Citations

Sep 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation·H KelbaekS L Nielsen
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·R R RussellL H Young
Jan 24, 2002·Japanese Heart Journal·I DemirM K Balci
Jul 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·B M Fisher, B M Frier
Apr 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·G GrossmannV Hombach
Nov 22, 2005·Seminars in Nephrology·Robert D Toto

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