Left ventricular diastolic function in young adults: the Coronary Artery Risk Development in Young Adults Study

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
X XieK Liu

Abstract

Doppler transmitral flow velocities have been used to assess left ventricular diastolic function. Associations of transmitral velocities with specific physiologic variables and cardiovascular risk factors have not been reported previously in a large population-based study of young adults. We performed Doppler analysis of left ventricular inflow in 3492 black and white men and women (aged 23 to 35 years) in the year-5 examination of the Coronary Artery Risk Development in Young Adults (CARDIA) Study. First third filling fraction, peak flow velocity in early diastole (PFVE), peak flow velocity in late diastole (PFVA), and the PFVA/PFVE ratio were measured. Women had higher PFVE and PFVA than had men (PFVE: 0.81 +/- 0.13 m/sec versus 0.76 +/- 0.13 m/sec; PFVA: 0.47 +/- 0.11 m/sec versus 0.43 +/- 0.10 m/sec; both p < 0.001). Gender-specific multiple regression analyses showed that age, heart rate, systolic blood pressure, left ventricular percent fractional shortening, and body weight were independently and positively related to PFVA (all p < 0.001) in men and women. Age, heart rate, and forced expiratory lung capacity in 1 second were inversely related to PFVE and first third filling fraction (both p < 0.01). Left ventricular perc...Continue Reading

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Citations

Aug 26, 1998·The American Journal of Cardiology·J M GardinD W Kitzman
Apr 12, 2007·Chest·Barbara LichodziejewskaDanuta Liszewska-Pfejfer
Sep 6, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Chintan S DesaiDonald M Lloyd-Jones
Jul 8, 2008·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·T GermansA C van Rossum
Jul 1, 1997·Journal of the American Geriatrics Society·L H Kuller, J S Gottdiener

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