Left ventricular diastolic function of remodeled myocardium in dogs with pacing-induced heart failure

The American Journal of Physiology
S B SolomonE L Yellin

Abstract

In patients with heart failure, decreased contractility resulting in high end-diastolic pressures and a restrictive pattern of left ventricular filling produces a decrease in early diastolic filling, suggesting a stiff ventricle. This study investigated the elastic properties of the myocardium and left ventricular chamber and the ability of the heart to utilize elastic recoil to facilitate filling during pacing-induced heart failure in the anesthetized dog. Elastic properties of the myocardium were determined by analyzing the myocardial stress-strain relation. Left ventricular chamber properties were determined by analyzing the pressure-volume relation using a logarithmic approach. Elastic recoil was characterized using a computer-controlled mitral valve occluder to prevent transmittral flow during diastole. We conclude that, during heart failure, the high end-diastolic pressures suggestive of a stiff ventricle are due not to stiffer myocardium but to a ventricle whose chamber compliance characteristics are changed due to geometric remodeling of the myocardium. The restrictive filling pattern is a result of the ventricle being forced to operate on the stiff portion of the diastolic pressure-volume relation to maintain cardiac o...Continue Reading

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Citations

Nov 3, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Gerd Heusch
Feb 7, 2019·Journal of Veterinary Pharmacology and Therapeutics·Telma Mary NakataRyou Tanaka
Mar 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Naoki FujimotoBenjamin D Levine

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