PMID: 9420835Nov 1, 1995Paper

Left ventricular diastolic function: physiology, methods of assessment, and clinical significance

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
J A Arrighi, R Soufer

Abstract

Diastole, that portion of the cardiac cycle that begins with isovolumic relaxation and ends with mitral valve closure, results in ventricular filling and involves both active (energy-dependent) and passive processes. The interactions between active processes (myocardial relaxation) that primarily influence early ventricular filling and passive processes, such as loading conditions, myocardial compliance, and valvular disease, are complex. Clinical methods to assess ventricular filling include cardiac catheterization, radionuclide angiography, and echocardiography. Any measurements of diastolic function must be made with an understanding of the determinants of ventricular filling and the limitations of the diagnostic test. Many cardiac disorders are characterized by elevated pulmonary venous pressures in the face of normal systolic ventricular function, which suggests a primary abnormality of diastolic function. Abnormalities in diastolic function have been observed in coronary artery disease, congestive heart failure (with and without systolic dysfunction), hypertrophic cardiomyopathy, hypertension, and in healthy elderly subjects. Identification of these abnormalities may be useful clinically, particularly in patients with sym...Continue Reading

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Citations

Jan 29, 2008·European Journal of Nuclear Medicine and Molecular Imaging·B HesseR Underwood
Sep 18, 2001·Heart·H SongY Nakashima
Apr 12, 2014·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Yuting LiuXiuhua Yang
Mar 4, 2008·Heart Failure Clinics·Wei ZhaoMani A Vannan
Sep 1, 2015·Canadian Journal of Physiology and Pharmacology·Christopher W WhiteDarren Freed
Jul 29, 2005·Journal of the American Society of Nephrology : JASN·Julian R WrightPhilip A Kalra
Oct 24, 2019·Heart Failure Reviews·Michael J BoniosStamatis N Adamopoulos
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·R R RussellL H Young

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