Left Ventricular Diastolic Myocardial Stiffness and End-Diastolic Myofibre Stress in Human Heart Failure Using Personalised Biomechanical Analysis

Journal of Cardiovascular Translational Research
Zhinuo J WangJ Jane Cao

Abstract

Understanding the aetiology of heart failure with preserved (HFpEF) and reduced (HFrEF) ejection fraction requires knowledge of biomechanical factors such as diastolic myocardial stiffness and stress. Cine CMR images and intra-ventricular pressure recordings were acquired in 8 HFrEF, 11 HFpEF and 5 control subjects. Diastolic myocardial stiffness was estimated using biomechanical models and found to be greater in HFrEF (6.4 ± 1.2 kPa) than HFpEF (2.7 ± 0.6 kPa, p < 0.05) and also greater than control (1.2 ± 0.4 kPa, p < 0.005). End-diastolic mid-ventricular myofibre stress derived from the personalised biomechanics model was higher in HFrEF (2.9 ± 0.3 kPa) than control (0.9 ± 0.3 kPa, p < 0.01). Chamber stiffness, measured from the slope of the diastolic pressure-volume relationship, is determined by the intrinsic tissue properties as well as the size and shape of the heart, and was unable to distinguish between any of the three groups (p > 0.05). Personalised biomechanical analysis may provide more specific information about myocardial mechanical behaviour than global chamber indices, which are confounded by variations in ventricular geometry.

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Citations

Jan 20, 2020·International Journal for Numerical Methods in Biomedical Engineering·Zhinuo J WangMartyn P Nash
May 26, 2020·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·J O CamposB M Rocha
Mar 5, 2020·European Heart Journal·Jorge Corral-AceroPablo Lamata
Oct 22, 2020·Medical Engineering & Physics·Gerardo Kenny RumindoPatrick Clarysse
Mar 23, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Zhinuo J WangBlanca Rodriguez
Jul 23, 2021·The Journal of Clinical Investigation·Mathilde Csc VermeerPeter van der Meer
Sep 13, 2021·The Journal of Physiology·Edith JonesBrian E Carlson
Nov 2, 2021·Frontiers in Physiology·Gonzalo D Maso TalouMartyn P Nash

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