PMID: 8967359Apr 11, 1996Paper

Left ventricular diastolic suction with zero left atrial pressure in open-chest dogs

The American Journal of Physiology
N B IngelsD C Miller

Abstract

We investigated left ventricular (LV) diastolic volume changes (suction inflows) with left atrial pressure (LAP) clamped to ambient pressure in six open-chest, anesthetized dogs. The left atrium was cannulated and connected to a servo pump, and LAP was clamped to a set point near 0 mmHg for four beats by withdrawing blood. LAP averaged 5.88 +/- 1.44 mmHg before the clamp and fell to 0.74 +/- 0.61 mmHg (P < 0.0001) after the clamp. During the first clamped beat a transmitral pressure gradient of 1.0 +/- 0.6 mmHg was observed, resulting in LV filling of 2.6 +/- 1.8 ml. Subsequent beats developed suction-driven (mean negative LV pressure: -1.5 +/- 1.3 mmHg; P < 0.005 vs. zero) LV filling of 4.5 +/- 2.8 ml/beat with a peak transmitral pressure gradient of 1.7 +/- 0.6 mmHg. These data are consistent with the hypothesis that LV suction can be an important filling mechanism under condition in which LV end-systolic volume is reduced, e.g., reduced filling pressures, high heart rates, exercise, or increased inotropic drive.

Citations

May 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·C CarlhällN B Ingels
Dec 14, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sydney L GaynorMarc R Moon
Feb 24, 2001·Journal of Biomechanical Engineering·J A VierendeelsP R Verdonck
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·G S NelsonJ V Tyberg
Feb 2, 2008·Journal of Applied Physiology·Todd A DorfmanBenjamin D Levine
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Zhibin WangJohn V Tyberg
Aug 11, 2006·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Liang ZhongLeok P Chua

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