PMID: 2113970Jun 1, 1990Paper

Left ventricular dysfunction following ligation of the ductus arteriosus in the preterm baboon

The Journal of Surgical Research
A F TaylorR A deLemos

Abstract

We evaluated the effect of early closure of the patent ductus arteriosus (PDA) on cardiac performance in a preterm baboon model of hyaline membrane disease. Eleven baboon fetuses were delivered at 75% gestation, resuscitated, and treated with conventional ventilation. The animals were divided into two groups, and underwent left thoracotomy at 2 hr of age. Group 1 (N = 5) had ductal infiltration with formalin to maintain ductal patency. Group 2 (N = 6) had ductal ligation. Hemodynamic parameters were compared between groups before and after surgical intervention. Examination of cardiovascular function was performed at intervals over a 24-hr period using two-dimensional, M-mode, and pulsed Doppler echocardiography. Ventricular performance was significantly worse in the ligation animals as demonstrated by reduced left and right ventricular outputs and reduced left ventricular shortening. However, pulmonary disease and arterial blood gases were not different. Early ligation was also associated with significantly increased systemic vascular resistance. We conclude that early ductal ligation leads to impaired ventricular performance in the premature primate. We hypothesize that the PDA may protect the immature ventricle by preventing...Continue Reading

References

Oct 1, 1989·Journal of Molecular and Cellular Cardiology·J E HixsonR A Walsh
Nov 1, 1987·The Journal of Pediatrics·E KruegerR Cotton
Jan 1, 1986·Pediatric Cardiology·C HammermanS Valaitis
Jun 1, 1987·Critical Care Medicine·B A YoderN B Ackerman
Nov 1, 1987·The Journal of Pediatrics·R I Clyman, D Campbell
Jan 1, 1986·Scandinavian Journal of Thoracic and Cardiovascular Surgery·P G Bjørnstad, B K Semb
Jan 1, 1972·Radiology·R GramiakP M Shah
Jun 1, 1984·Critical Care Medicine·N B AckermanR deLemos
Dec 1, 1982·Experimental and Molecular Pathology·J J CoalsonJ L Robotham

❮ Previous
Next ❯

Citations

May 25, 2006·Acta Paediatrica·Lilian S Teixeira, Patrick J McNamara
Nov 19, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·M D SatputeS W Aucott
Mar 12, 2013·The Journal of Thoracic and Cardiovascular Surgery·Hazumu NagataToshiro Hara
Feb 16, 2013·The Journal of Pediatrics·Afif F El-KhuffashPatrick J McNamara
Dec 30, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Joshua P KanterRobert H Pass
Jul 11, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·L S TeixeiraP J McNamara
Oct 8, 2005·Biology of the Neonate·Eduardo BancalariAlvaro Gonzalez
Jun 24, 2008·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Matthew T HartingKevin P Lally
May 22, 2021·The Journal of Pediatrics·Jose Carlos Aldana-AguirreDany E Weisz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.