Left Ventricular End-Systolic Eccentricity Index for Assessment of Pulmonary Hypertension in Infants

Echocardiography
Sharon Abraham, Constance G Weismann

Abstract

Pulmonary hypertension (PH) is a common problem in the neonatal intensive care unit and is associated with significant morbidity and mortality. The aim of this study was to identify a quantitative echocardiographic marker of septal curvature that can be used to accurately identify PH in NICU infants with concern for PH. Echocardiograms of infants who were prematurely born and infants with persistent pulmonary hypertension of the newborn were performed using a defined protocol for evaluation of PH. Qualitative assessment by a single pediatric cardiologist was used as a reference standard. Qualitative and quantitative parameters of right ventricular (RV) size, pressure, and function were documented. Left ventricular end-systolic eccentricity index (EI) was defined as the ratio of the anterior-inferior and septal-posterolateral cavity dimensions at the mid-ventricular level. A total of 216 infants at risk for PH were included in this study. One hundred forty-three (66%) had an interpretable tricuspid regurgitation jet velocity. While systolic septal flattening was recognized at EIs ≥ 1.15, more than half-systemic RV pressure became apparent at EIs ≥ 1.3. Unlike qualitative assessment of septal flattening, there was high inter-obse...Continue Reading

References

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Citations

Feb 17, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·C G WeismannM J Bizzarro
Sep 8, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·A M KunjunjuA Sehgal
Dec 15, 2018·Pediatric Pulmonology·Sakeer VayalthrikkovilAmuchou Soraisham
Nov 23, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Andrew W McCraryMatthew M Laughon
Feb 28, 2019·Congenital Heart Disease·Govinda Paudel, Vijaya Joshi
Jun 4, 2019·Biomarkers in Medicine·Moises Rodriguez-GonzalezSimon Pedro Lubian-Lopez
Sep 21, 2019·American Journal of Respiratory and Critical Care Medicine·Paul J CritserJason C Woods
Mar 7, 2020·Pediatric Pulmonology·Anna Claudia MassoloAnnabella Braguglia
Oct 2, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Shilpa Vyas-ReadUNKNOWN Children’s Hospitals Neonatal Consortium Severe BPD Focus Group
May 16, 2020·Circulation. Cardiovascular Imaging·Dale A BurkettD Dunbar Ivy
Feb 26, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Anna Claudia MassoloAlessandra Toscano
Jul 24, 2020·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Paul J CritserJason C Woods
Nov 16, 2019·Journal of Cardiovascular Echography·Wai Huang TengBenjamin G Shelley
Apr 6, 2021·Pediatric Pulmonology·Reem M SolimanHany Aly
Apr 9, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Moisés Rodríguez-GonzálezJose Carlos Flores-González

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