Peak rapid filling rate (PRFR) is often used clinically as an index of left ventricular relaxation, i.e., of early diastolic function. This study tests the hypothesis that early filling rate is a function of the atrioventricular pressure difference and hence is influenced by the left atrial pressure as well as by the rate of left ventricular relaxation. As indexes, we chose the left atrial pressure at the atrioventricular pressure crossover (PCO), and the time constant (T) of an assumed exponential decline in left ventricular pressure. We accurately determined the magnitude and timing of filling parameters in conscious dogs by direct measurement of phasic mitral flow (electromagnetically) and high-fidelity chamber pressures. To obtain a diverse hemodynamic data base, loading conditions were changed by infusions of volume and angiotensin II. The latter was administered to produce a change in left ventricular pressure of less than 35% (A-1) or a change in peak left ventricular pressure of greater than 35% (A-2). PRFR increased with volume loading, was unchanged with A-1, and was decreased with A-2; T and PCO increased in all three groups (p less than .005 for all changes). PRFR correlated strongly with the diastolic atrioventricu...Continue Reading
Pressure-flow and pressure-volume relations in the entire pulmonary vascular bed of the dog determined by two-port analysis.
Effects of timing of atrial systole on LV filling and mitral valve closure: computer and dog studies
Left ventricular relaxation in patients with left ventricular hypertrophy secondary to aortic valve disease
Hemodynamic correlates for timing intervals, ejection rate and filling rate derived from the radionuclide angiographic volume curve
Left ventricular relaxation and filling pattern in different forms of left ventricular hypertrophy: an echocardiographic study
Comparison of the effects of nitroprusside and nifedipine on diastolic properties in patients with hypertrophic cardiomyopathy: altered left ventricular loading or improved muscle inactivation?
Effects of short-term administration of verapamil on left ventricular relaxation and filling dynamics measured by a combined hemodynamic-ultrasonic technique in patients with hypertrophic cardiomyopathy
Transmitral blood flow reflecting diastolic behavior of the left ventricle in health and disease--a study by pulsed Doppler technique
Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy
Volume loading slows left ventricular isovolumic relaxation rate. Evidence of load-dependent relaxation in the intact dog heart
Impaired left ventricular diastolic filling in patients with coronary artery disease: assessment with radionuclide angiography
Surgical aortic valvuloplasty using the Cavitron Ultrasonic Surgical Aspirator: an invasive hemodynamic follow-up study
Long-term prognostic value of an index of myocardial performance in patients with myocardial infarction
Role of transmitral blood flow velocity by Doppler echocardiography in the evaluation of coronary artery disease.
Effects of intravenous digoxin on pulmonary venous and transmitral flows in patients with chronic heart failure of different degrees
Transesophageal pulsed Doppler echocardiographic evaluation of left atrial systolic performance in hypertrophic cardiomyopathy: combined analysis of transmitral and pulmonary venous flow velocities
Treatment of hypertension with perindopril reduces plasma atrial natriuretic peptide levels, left ventricular mass, and improves echocardiographic parameters of diastolic function
Gradient echo MRI for measurement of the pulmonary autograft diameter after transplantation to the aortic root: validation and comparison with ultrasound
Assessment of left ventricular function after sublingual administration of nifedipine in patients with moderate to severe hypertension
Effects of acute administration of gallopamil on left ventricular relaxation and filling dynamics in acute myocardial infarction assessed by Doppler echocardiography
Acute loads applied to the right ventricle: effect on left ventricular filling dynamics in the presence of an open pericardium
Role of gestational age and body weight on Doppler transmitral flow velocity pattern in very low birth weight infants
Pulmonary venous stenosis as an associated manifestation of left-sided obstructive lesions in an infant with partial atrioventricular canal defect
New observations from MR velocity-encoded flow measurements concerning diastolic function in constrictive pericarditis
Early diastolic mitral annular velocity and color M-mode flow propagation velocity in the evaluation of left ventricular diastolic function in patients with Fabry disease
Comparison of early diastolic annular velocities measured at various sites of mitral annulus in detection of mild to moderate left ventricular diastolic dysfunction
Combined use of propagation velocity and intraventricular dispersion of E wave velocity for the evaluation of diastolic functions in patients with rheumatoid arthritis
Evaluation of left ventricular diastolic function by pulmonary venous and mitral flow velocity patterns in endurance veteran athletes
Effects of changes in coronary stenosis on left ventricular diastolic filling assessed with pulsed Doppler echocardiography.
Effect of postural changes, nitroglycerin and verapamil on diastolic ventricular function as determined by radionuclide angiography in normal subjects
Relation of transmitral flow velocity patterns to left ventricular diastolic function: new insights from a combined hemodynamic and Doppler echocardiographic study
Peak filling rate normalized to mitral stroke volume: a new Doppler echocardiographic filling index validated by radionuclide angiographic techniques
Effect of nitroglycerin-induced reduction of left ventricular filling pressure on diastolic filling in acute dilated heart failure
Left ventricular diastolic function: comparison of pulsed Doppler echocardiographic and hemodynamic indexes in subjects with and without coronary artery disease
Effect of inotropic and vasodilator therapy on left ventricular diastolic filling in dogs with severe left ventricular dysfunction.
Relation between extent of left ventricular hypertrophy and diastolic filling abnormalities in hypertrophic cardiomyopathy.
Analysis of the early transmitral Doppler velocity curve: effect of primary physiologic changes and compensatory preload adjustment
Reduction of left ventricular preload by lower body negative pressure alters Doppler transmitral filling patterns
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