PMID: 9435600Jan 22, 1998Paper

Left ventricular function and remodeling after myocardial infarction in aging rats

The American Journal of Physiology
T E RayaS Goldman

Abstract

Adaptations of the aging left ventricle (LV) to hemodynamic overload are functionally and structurally distinct from those of the young organism. This study describes the influence of aging on LV hemodynamics and remodeling late after myocardial infarction (MI) in Fischer 344 Brown Norway rats. In sham rats at 23 mo, LV weight, myocyte cross-sectional area (CSA), and myocardial fibrosis were increased, whereas LV dP/dt, LV relaxation, and maximal LV systolic function declined with respect to younger rats (7, 12, and 18 mo of age). Isometric myocardial function was evaluated in papillary muscles of 12- and 23-mo-old sham rats. Myocardial systolic function was decreased in older rats. To determine how aging affects LV function and remodeling after MI, rats were infarcted at 7 and 18 mo of age and were studied 5 mo later. Infarct size was similar in each group. Right ventricular weight, LV end-diastolic pressure, and volume index were increased, whereas LV dP/dt, peak cardiac index, and peak developed LV pressure declined after MI. However, there were no significant differences between young and older rats in any variable of LV systolic function or remodeling after MI. Myocyte CSA increased in younger rats after MI but was unchang...Continue Reading

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Citations

May 6, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Dongqing CaiJay M Edelberg
May 9, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Joost LumensAlistair A Young
Jul 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·David JeggerNikolaos Stergiopulos
Sep 7, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Timothy A HackerJudd M Aiken
May 22, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jonathan AfilaloGustavo Duque
Oct 8, 2009·International Heart Journal·Danilo Sales Bocalini, Paulo Jose Ferreira Tucci
Jul 8, 2017·Journal of Applied Physiology·Vinicius GuzzoniHeloísa Sobreiro Selistre-de-Araújo
May 20, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John T LilesCraig F Plato
Mar 3, 2021·GeroScience·Aykhan YusifovDanielle R Bruns

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