Left ventricular function, tricuspid incompetence, and incidence of coronary artery disease late after orthotopic heart transplantation

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
G HerrmannH G Borst

Abstract

Functional results and data concerning the incidence and severity of graft atherosclerosis (GASC) and tricuspid incompetence (TI) in the intermediate term after orthotopic heart transplantation (HTX) are still striking. We examined 92 patients 1, 2, and 3 years after HTX by right and left heart catheterization in order to evaluate pump function, the status of the coronary arteries and the extend of TI, using a double indicator thermodilation technique. Mean left ventricular volumes and ejection fraction were normal 1 and 2 years post-transplant. The incidence of GASC was 8/87 (9.2%) at 1, and 11/92 (12%) at 2 years. It was more frequent (16%) in patients with preexisting coronary artery disease (IHD) than in patients with underlying dilative cardiomyopathy (DCM) (11%). At the end of the 1st postoperative year, 62% of patients were free of TI, whereas only 38% had normal valve function 2 years posttransplant. In 9/14 (64%) of patients, consecutively assessed at 1 and 2 years, TI had increased between both investigations. Preoperative haemodynamics, the number of endomyocardial biopsies and rejection episodes as well as preoperative cardiac size did not correlate with TI. Left ventricular volumes and ejection fraction are normal ...Continue Reading

Citations

Jan 1, 1992·Journal of the American College of Cardiology·M D TischlerJ D Parker
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lisa MielniczukJohn P Veinot
Jan 22, 1998·The Annals of Thoracic Surgery·R HetzerH G Borst
Oct 30, 1999·The Annals of Thoracic Surgery·T M AzizN A Yonan
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·T WahlersH G Borst
May 23, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Maria WartigGöran Dellgren
Aug 1, 1996·Mayo Clinic Proceedings·W T VigneswaranC G McGregor
Oct 1, 1990·The American Journal of Cardiology·A MüggeP R Lichtlen
Jun 1, 1995·The Annals of Thoracic Surgery·R G LeyhH H Sievers
Apr 1, 1994·The Annals of Thoracic Surgery·C B HuddlestonM K Pasque
Feb 13, 2001·The American Journal of Cardiology·A AliH O Ventura
Dec 22, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jing Ping SunJames D Thomas
Jun 27, 2000·Medical Hypotheses·M M Klapheke
Jan 1, 1994·Scandinavian Journal of Thoracic and Cardiovascular Surgery·L WiklundE Berglin

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