Abstract
This study aimed to evaluate the left ventricular (LV) functions in a cohort of children with Graves' disease (GD). This is a cross-sectional case-control study. It included 36 children with GD and 36 healthy children matched for age and gender. Thyroid hormones (TSH, FT4, and FT3) and anti-thyroid autoantibodies [anti-thyroid peroxidase (anti-TPO), thyrotropin receptor (TRAbs), and thyroglobulin antibodies] were measured. Conventional and tissue Doppler imaging (TDI) echocardiographies were used to assess left ventricular systolic and diastolic functions. LV mass index (LVMI) and myocardial performance index (MPI) were also measured. Compared to healthy children, conventional echocardiography of patients with GD revealed higher LVMI (P = 0.001) indicating LV hypertrophy but normal LV functions while TDI revealed lower Em/Am ratio indicating LV diastolic dysfunction (P = 0.001). Significant correlations were reported between FT4 with LVMI (P = 0.05), Em/Am (P = 0.01), and MPI (P = 0.01). In multivariate analysis, a positive correlation was identified between FT4 with MPI (OR = 1.17; 95% CI = 1.09-1.15; P = 0.001). Children with newly diagnosed GD may have significant subclinical changes in LV structure and function (diastolic a...Continue Reading
References
Dec 1, 1978·Circulation·D J SahnA Weyman
Jul 1, 1991·The Journal of Clinical Endocrinology and Metabolism·G MintzI Klein
Feb 1, 1970·Archives of Disease in Childhood·W A Marshall, J M Tanner
Dec 1, 1984·Journal of the American College of Cardiology·R B DevereuxJ H Laragh
Aug 1, 1994·Circulation Research·E KissI Edes
Apr 1, 1996·Heart·G W ChingM D Gammage
Apr 16, 1998·Endocrinology and Metabolism Clinics of North America·D Zimmerman, A N Lteif
Mar 27, 2001·Journal of the American College of Cardiology·G P AurigemmaD Kitzman
Aug 8, 2002·Thyroid : Official Journal of the American Thyroid Association·W H Dillmann
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Sep 6, 2003·International Journal of Cardiology·M DonatelliG Licata
Nov 4, 2004·The Journal of Clinical Endocrinology and Metabolism·Marcus DörrHenry Völzke
Jan 6, 2005·Endocrine Reviews·George J Kahaly, Wolfgang H Dillmann
Jul 14, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Wei CuiBettina F Cuneo
Aug 7, 2007·Endocrine Journal·Carlo CappelliEnrico Agabiti Rosei
Aug 30, 2008·Current Heart Failure Reports·Peter DahlIrwin Klein
Jan 7, 2009·Heart Failure Reviews·Wolfgang Dillmann
Mar 10, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Sherif F NaguehArturo Evangelisa
May 29, 2010·Bosnian Journal of Basic Medical Sciences·Almira Hadzović-DzuvoOrhan Lepara
Aug 24, 2011·Journal of Thyroid Research·Gulbanu ErkanAtiye Cengel
Sep 17, 2013·Thyroid : Official Journal of the American Thyroid Association·Greet L RoefJean-Marc Kaufman
Oct 10, 2013·BioMed Research International·Lucia Oliveros-RuizJ Antonio G Hermosillo