Left ventricular geometric patterns and QT dispersion in borderline and mild hypertension: their evolution and regression

American Journal of Hypertension
H TomiyamaS Hinohara

Abstract

To investigate whether QT dispersion increases in borderline and mild hypertension during a longitudinal observation of > 3 years and whether it is improved with medications, left ventricular geometric patterns and QT dispersion were studied with special regard to their longitudinal changes in 85 male borderline and mild hypertensive subjects with left ventricular mass index < 125 g/m2. These subjects were followed for > 3 years without medication. Thirty-two patients with a left ventricular mass index > 125 g/m2 at the end of follow-up period were further observed using antihypertensive drugs for an additional 3 years. Echocardiograms and electrocardiograms were obtained at the beginning and end of the follow-up period. At the end of the follow-up period, subjects were classified into four groups based on ventricular geometric patterns determined by left ventricular mass index and relative wall thickness in diastole. The QT dispersion was greater in patients with concentric hypertrophy (56+/-18 msec) than in patients with normal geometry (41+/-17 msec) (P < .05) and increased significantly in the former group during the follow-up period. After medication, the left ventricular mass index regressed and the QT dispersion decrease...Continue Reading

Citations

Apr 25, 2000·Journal of Hypertension·B GryglewskaJ Kocemba
May 23, 2007·Clinical Drug Investigation·Thomas S MirJochen Weil
Mar 20, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jan KlimasSimon W Rabkin
Nov 7, 2019·Journal of Diabetes·José Silva-CardosoRobert J Chilton
Jan 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Francine C de CarvalhoMauricio Wajngarten

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.