Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry.

Frontiers in Cardiovascular Medicine
Filip ZemrakSteffen E Petersen

Abstract

Aim: Left ventricular non-compaction (LVNC) is perceived as a rare high-risk cardiomyopathy characterized by excess left ventricular (LV) trabeculation. However, there is increasing evidence contesting the clinical significance of LV hyper-trabeculation and the existence of LVNC as a distinct cardiomyopathy. The aim of this study is to assess the association of LV trabeculation extent with cardiovascular morbidity and all-cause mortality in patients undergoing clinical cardiac magnetic resonance (CMR) scans across 57 European centers from the EuroCMR registry. Methods and Results: We studied 822 randomly selected cases from the EuroCMR registry. Image acquisition was according to international guidelines. We manually segmented images for LV chamber quantification and measurement of LV trabeculation (as per Petersen criteria). We report the association between LV trabeculation extent and important cardiovascular morbidities (stroke, atrial fibrillation, heart failure) and all-cause mortality prospectively recorded over 404 ± 82 days of follow-up. Maximal non-compaction to compaction ratio (NC/C) was mean (standard deviation) 1.81 ± 0.67, from these, 17% were above the threshold for hyper-trabeculation (NC/C > 2.3). LV trabeculat...Continue Reading

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Citations

Jul 3, 2021·Journal of Clinical Medicine·Birgit J Gerecke, Rolf Engberding
Aug 1, 2021·European Radiology·Fabrizio RicciSteffen E Petersen
Jul 16, 2021·Progress in Cardiovascular Diseases·Fatemeh AdabifirouzjaeiAnthony Nicholas DeMaria

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

R
cvi42
R Core

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