PMID: 2485019Jan 1, 1987Paper

Left ventricular hypertrophy and risk of cardiac failure: insights from the Framingham Study

Journal of Cardiovascular Pharmacology
W B KannelL A Cupples

Abstract

The incidence of congestive heart failure (CHF), derived from more than 30 years of follow-up, is examined by electrocardiogram (ECG) and radiography in relation to cardiac hypertrophy. Cardiac failure occurred in 485 of 5,209 subjects participating in the Framingham Study. Hypertension was the dominant predisposing factor for both cardiac hypertrophy and cardiac failure. The ECG pattern of left ventricular hypertrophy (ECG-LVH) heralded serious cardiovascular disease of all varieties, but risk ratios were two- to fivefold greater for the development of CHF in men and women (ages 35-64 years) than for any other sequelae. Risk of CHF in those with ECG-LVH exceeded that for unrecognized ECG patterns at myocardial infarction (ECG-MI). The ECG pattern of left ventricular hypertrophy, characterized by increased voltage unaccompanied by a repolarization abnormality, carried a decreased risk, chiefly reflecting the severity of coexistent hypertension. The independent contribution of ECG-LVH with accompanying repolarization changes to the risk of CHF was equal in the two sexes and persisted with advancing age. The ECG pattern of left ventricular hypertrophy was more strongly associated with occurrence of CHF than was radiographic enlar...Continue Reading

Citations

Aug 4, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Tochi M OkwuosaKim A Williams
Jan 14, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Dec 31, 2005·Circulation Research·Ying Jia, Koichi Takimoto
Dec 29, 2009·Frontiers in Bioscience (Scholar Edition)·Sharon TsangRui-Ping Xiao
Mar 1, 1995·Clinical Cardiology·K T Weber
Mar 29, 2001·Clinical and Experimental Hypertension : CHE·G IaccarinoB Trimarco
Nov 22, 2014·IEEE Journal of Biomedical and Health Informatics·Avan SuinesiaputraAlistair Young
Jan 10, 2006·The American Journal of Cardiology·Paolo ColonnaItalo de Luca
Apr 16, 1998·Scandinavian Cardiovascular Journal. Supplement·H Schunkert
Apr 2, 2011·Expert Review of Cardiovascular Therapy·Rajesh Janardhanan, Christopher M Kramer
Aug 11, 2011·European Journal of Preventive Cardiology·Gabriel ArefalkJohan Sundström
Sep 24, 2016·Journal of Hypertension·Maria L MuiesanUNKNOWN Moli-sani Study Investigators
Oct 22, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Abe DeAnda
Aug 28, 2004·The Medical Clinics of North America·Satish KenchaiahRamachandran S Vasan
Aug 28, 2004·The Medical Clinics of North America·Satish KenchaiahRamachandran S Vasan
Feb 18, 2016·Therapeutic Advances in Cardiovascular Disease·Mary VargheseKiron Varghese
Sep 4, 2010·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Matthijs F L MeijsUNKNOWN SMART study group
Dec 1, 1990·Circulation Research·C G BrillaK T Weber
Apr 28, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Modar KassanKhalid Matrougui
Nov 17, 2016·Hypertension·George A MensahGary H Gibbons
Nov 28, 2001·The Journal of Clinical Hypertension·L M Prisant
Aug 28, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Pau Medrano-GraciaAlistair A Young
Jul 9, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Allen J TaylorPatrick G O'Malley
Aug 30, 2012·The Journal of Physiology·Kimberley C W WangJanna L Morrison
Jan 30, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kimberley C W WangJanna L Morrison

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