Left ventricular hypertrophy identified by cardiac computed tomography and ECG in hypertensive individuals: a population-based study

Journal of Hypertension
Jørgen Tobias KühlKlaus Fuglsang Kofoed

Abstract

Screening of left ventricular hypertrophy (LVH) is a biomarker of organ damage in hypertensive individuals and associated with increased mortality. Cardiac computed tomography (CT) is widely expanding worldwide; however, the value of CT assessment of LVH is unknown. We aimed to identify individuals with LVH using both cardiac CT and electrocardiograms (ECG) and to explore potential differences between these phenotypical distinct diagnostic modalities. Participants in the Copenhagen General Population Study underwent 12-lead ECG and cardiac CT and were evaluated for the presence of LVH. Multiple ECG signs of LVH were compared with LVH by CT. Out of 4942 participants, 1347 had untreated hypertension and in this group, 13% presented with anatomical LVH by CT and 10% by ECG with an overlap of 4%. ECG signs of LVH had negative predictive values between 87 and 89% compared with CT. Using a combination of the Sokolow-Lyon index, the Cornell voltage duration product and/or a Romhilt-Estes score at least 4, lead to an increased C-statistics (P < 0.001) compared with the use of any single ECG sign of LVH. Individuals with solely CT but not ECG signs of LVH had higher SBPs (152 vs. 144 mmHg, P < 0.001) and larger left atria (49 vs. 45 ml/...Continue Reading

References

Nov 1, 1992·Journal of the American College of Cardiology·T J MolloyP Kligfield
Sep 1, 1985·Journal of the American College of Cardiology·P N CasaleM C Phillips
Oct 1, 1994·The American Journal of Cardiology·G SchillaciC Porcellati
Nov 11, 1998·Journal of the American College of Cardiology·A W HaiderD Levy
Mar 7, 2001·American Heart Journal·B A VakiliR B Devereux
Jul 18, 2003·The American Journal of Medicine·Arnfried U KlingbeilRoland E Schmieder
Sep 14, 2007·Blood Pressure·Thomas SehestedtTorben Jørgensen
May 28, 2010·Clinical and Experimental Hypertension : CHE·Alberto CalderónJosefa Navarro-Cid
Apr 16, 2013·Journal of the American College of Cardiology·Jonas Bille NielsenAnders Gaarsdal Holst
Jan 13, 2015·Journal of Cardiovascular Computed Tomography·Ricardo C Cury
Apr 29, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jonas B NielsenAnders G Holst

❮ Previous
Next ❯

Citations

Jul 11, 2020·Therapeutic Advances in Chronic Disease·Begoña Quintana-VillamandosMaria Carmen González

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.