PMID: 9426038Jan 13, 1998Paper

Left ventricular length-force-shortening relations before and after surgical correction of chronic mitral regurgitation

Journal of the American College of Cardiology
H GoldfineW H Gaasch

Abstract

We tested the hypothesis that postoperative left ventricular (LV) systolic wall stress can be predicted from the change in LV diastolic dimension and ejection fraction (EF) after surgical correction of chronic mitral regurgitation (MR). We used a simple mathematic model to predict postoperative systolic stress from end-diastolic dimension and EF. The validity of this model was assessed using data from 21 patients undergoing mitral valve replacement (MVR) for chronic MR. The decline in EF after MVR for chronic MR is traditionally thought to be a consequence of a postoperative increase in afterload, caused by closure of a low resistance runoff into the left atrium. However, consideration of the Laplace relation suggests that afterload does not necessarily increase after the operation. A spherical mathematical model of the left ventricle was used to define the relations between LV end-diastolic dimension, systolic wall stress and EF. To test the validity of this model, clinical and echocardiographic data were obtained from 21 patients with chronic MR before and 10 to 14 days after MVR. These echocardiographic data were examined with reference to plots derived from the mathematical model. Patients were categorized as those in whom ...Continue Reading

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Citations

May 7, 2003·Progress in Biophysics and Molecular Biology·John M PowerClif Alferness
Apr 17, 2002·Journal of the American College of Cardiology·William H Gaasch, Gerard P Aurigemma
Nov 6, 2009·Future Cardiology·Giovanni LandoniAlberto Zangrillo
Feb 19, 2005·Current Cardiology Reports·Naomi F BotkinGerard P Aurigemma
Mar 17, 2010·The Journal of Thoracic and Cardiovascular Surgery·Elena A AshikhminaMartin D Abel
Oct 2, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Giovanni LandoniAlberto Zangrillo
Jul 21, 2015·The Journal of Thoracic and Cardiovascular Surgery·Ken-ichi ImasakaYukihiro Tomita
Aug 12, 2008·The Journal of Thoracic and Cardiovascular Surgery·Rakesh M SuriThomas A Orszulak
Apr 16, 2011·Journal of the American College of Cardiology·Robert J SiegelUNKNOWN EVEREST Investigators
May 2, 2013·Circulation. Cardiovascular Imaging·Elyse FosterUNKNOWN EVEREST Investigators
Mar 3, 2006·Expert Review of Cardiovascular Therapy·Neville A G SolomonShiju Sukumaran
Nov 14, 1998·The American Journal of Physiology·A DeAndaD C Miller
May 17, 2021·Journal of Cardiac Surgery·Yun Seok Kim, Ju Yong Lim

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