PMID: 15374095Sep 18, 2004Paper

Left ventricular mass and heart rate variability in middle-aged and elderly salt-sensitive hypertensive subjects

Archives of Gerontology and Geriatrics
G PiccirilloV Marigliano

Abstract

Previous reports have shown that in salt-sensitive hypertension a high dietary salt intake can increase sympathetic activity. We evaluated the influence of the autonomic nervous system on myocardial hypertrophy by power spectral analysis of heart rate variability in middle-aged and elderly salt-sensitive hypertensive subjects. We compared autonomic nervous system activity in 32 salt-sensitive hypertensive patients (15 subjects with mean age, 42.4+/-2.4 years and 17 subjects with mean age, 74.6+/-1.6 years) and 20 age-matched normotensive controls. Power spectral analysis detects four spectral components: total power (TP), high-frequency (HF), low-frequency (LF) and very-low-frequency (VLF) power. In the elderly subjects we found an association between the left ventricular mass index (LVMI) and the following variables: very-low frequency (P<0.0001), 24-h urinary sodium excretion (P<0.0001) and diastolic blood pressure (DBP) (P<0.0001). In contrast, in middle-aged subjects we found a significant association between the LVMI and LF (P<0.001). In middle-aged, but not in elderly salt-sensitive hypertensive subjects, increased sympathetic activity correlated with the LVMI (P<0.0001). Our findings suggest an association between sympat...Continue Reading

References

Jan 1, 1991·Circulation·H E Morgan, K M Baker
Jul 5, 1986·British Medical Journal·D E Grobbee, A Hofman
Sep 13, 1986·British Medical Journal·D Simmons
Aug 1, 1993·Journal of the American College of Cardiology·J M SullivanD M Mirvis
Dec 1, 1996·Hypertension·G PiccirilloV Marigliano

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Citations

Sep 4, 2007·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Chanannait PaisansathanPeggy Wheeler
Jul 21, 2007·Journal of Clinical Monitoring and Computing·Chanannait PaisansathanPeggy Wheeler
Feb 27, 2007·Journal of Clinical Anesthesia·James FeldRanga C Ananda

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